Anti-idiotype antibodies, monoclonal

Geha R, Quinti I, Austen K, Cicardi M, Sheffer A, Rosen F Acquired Cl-inhibitor deficiency associated with anti-idiotypic antibody to monoclonal immunoglobuhns. N Engl J Med 1985 312 534-540. Donaldson V, Hess E, McAdams A Lupus-erythe-matosus-like disease in three umelated women with hereditary angioneurotic edema. Arm Intern Med 1977 86 312-313. 

Monoclonal antibody (or component) Hybridoma human cell line Probably predictable anitgenicity Moderate Anti-tumor antibody for imaging anti-idiotype antibody as vaccine... 

The most outstanding example illustrating this strategy came from the team of Alain Friboulet and Daniel Thomas, who produced anti-idiotype antibodies against a monoclonal antibody AE2 that was a competitive inhibitor of acetylcholine esterase. One of the selected antibodies, 9A8, catalyzes the hydrolysis of acetylthio-choline with a pseudo first-order rate constant /feat = 81 and a factor of acceleration of 4.2 x 10 . These remarkable parameters, which are only two orders of magnitude lower when compared to those of the enzyme, make abzyme 9A8 the most powerful abzyme known until now. 

The invention of B cell hybridoma technology (K3) has allowed the generation of various kinds of useful antibodies, even very minor or rare antibody species elicited in serum by the conventional procedure, as a pure immunochemical reagent in almost unlimited amounts. Among such new-generation monoclonal antibodies, anti-idiotype antibodies and anti-immune complex (anti-metatype) antibodies have been successfully introduced as key reagents enabling noncompetitive hapten immunoassays (Fig. 11). 

HAxA anti-idiotype antibodies against therapeutic monoclonal antibodies, such as HAMA (human anti-murine antibody), HACA (human anti-chimeric antibody), and HAHA (human anti-human antibody). 

Miller, R. A., Maloney, D. G., Warnke, R., and Levy, R. (1982). Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody. N. Engl.J. Med. 306, 517-522. 

Fagerberg J, Frodin JE, Wigzell H, Mellstedt H. Induction of an immune network cascade in cancer patients treated with monoclonal antibodies (abl). I. May induction of abl-reactive T cells and anti-anti-idiotypic antibodies (ab3) lead to tumor regression after mAb therapy Cancer Immunol Immunother 1993 37 264-70. 

Thielemans, K. Maloney, D.G. Meeker, T. Eujimoto, J. Doss, C. Warnke, R.A. Bindl, J. Gralow, J. Miller, R.A. Levy, R. Strategies for production of monoclonal anti-idiotype antibodies against human B-cell lymphomas. J.Immunol. 1984,133, 495-501. 

Conjugated monoclonal antibodies can be used as carriers of toxic therapy, such as radionuclides, (e.g., yttrium-90 ibritumomab tiuxetan and iodine-131 tositumomab), cytotoxic drugs, or cell toxins to specific cell targets. They are also being employed to create tumor vaccines by stimulating a host antibody reaction causing the production of anti-idiotype antibodies. 

Hamblin, T. J., Cattan, A. R., Glennie, M. J., Mackenzie, M. R., Stevenson, F. K Watts, H. F., and Stevenson, G. T. (1987) Initial experience in treating human lymphoma with a chimeric univalent derivative of monoclonal anti-idiotype antibody. Blood 69,790-797. 

Another approach was to develop antibody-based vaccines (anti idiotype) against T-2 toxin. Protective monoclonal antitoxin antibodies were first generated and then used to induce specific monoclonal anti idiotype antibodies. When mice were immunized with specific monoclonal antiidiotype antibodies, they developed neutralizing antibodies and were protected against challenge with a lethal dose of T-2 toxin.93 Thus, it would be feasible to develop a despeciated monoclonal antiidiotype antibody that could be a vaccine candidate against T-2 toxin. 

Despeciated monoclonal anti-idiotype antibody USAMRIID Preclinical... 

Sawada, S., Shida, M., Suenaga, R., Mizuma, H., Karasaki, M., Hashimoto, M., Kawano, K., and Amaki, I. (1986) Elicited antibody nature of human monoclonal protein with anti-streptolysin O activity-analysis with monoclonal anti-idiotype antibody. J. Clin. Lab. Immunol. 19, 31-35. 

Abagovomab is a murine monoclonal anti-idiotypic antibody that functionally imitates tumour antigen CA-125,... 

Jaffers GJ, Fuller TC, Cosimi AB, Russell PS, Winn HJ, Colvin RB. Monoclonal antibody therapy. Anti-idiotypic and non-anti-idiotypic antibodies to OKT3 arising despite intense immunosuppression. Transplantation 1986 41 572—578. 

Igarashi, K., Kaneda, M., Yamaji, A., Saido, T.C., Kikkawa, U., Qno, Y., Inoue, K., and Umeda, M., 1995, A novel phosphatidylserine-binding peptide motif defined by an anti-idiotypic monoclonal antibody. Localization of phosphatidylserine-specific binding sites on protein kinase C and phosphatidylserine decarboxylase. J. Biol. Chem. 270 29075-29078. 

Kl. Kobayashi, N., Oiwa, H., Kubota, K., Sakoda, S., and Goto, J., Monoclonal antibodies generated against an affinity-labeled immune complex of an anti-bile acid metabolite antibody An approach to noncompetitive hapten immunoassays based on anti-idiotype or anti-metatype antibodies. J. Immunol. Methods 245, 95-108 (2000). 

Feng, Z., Qiu, Z., Li, Y., Zhu, C., Xue, W. and Guan, X. (2002) Protective immunity induced by the anti-idiotypic monoclonal antibody NP30 of Schistosoma japonicum. Chinese Medical Journal (Engl.) 115, 576-579. 

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