Anti-emetic properties

A may cause tingling of extremities B is used in the prophylaxis of migraine C has anti-emetic properties D may be used in hepatic impairment E is a 5HT agonist... 

Nabilone (37) is a synthetic 9-ketocannabinoid with anti-emetic properties. One of the best of the various published routes to nabilone starts with the enolacetate of nopinone (33), which on short heating with lead tetraacetate undergoes allylic substitution to give Treatment with p-toluene-... 

The cannabinoids have previously been noted to have anti-emetic properties and nabilone has been available for the treatment of emesis due to chemotherapy for some years. Recently, there have been reports of its use in preventing postoperative nausea and vomiting in gynaecological patients with some limited success. 

Phenothiazines are antipsychotic agents that can be used for their potent anti emetic and sedative properties (see Chapter 29 Antipsychotic Agents Lithium). The anti emetic properties of phenothiazines are mediated through inhibition of dopamine and muscarinic receptors. Sedative properties are due to their antihistamine activity. The agents most commonly used as antiemetics are prochlorperazine, promethazine, and thiethylperazine. 

Documented effects Preparations from raspberries improve stomach and intestine function, have antiseptic, analgesic, antipyretic, expectorant, anti-inflammatory, and anti-emetic properties, and improve metabolism (Maznev 2004). Extracts of the fruits have antioxidant effects and exhibit antimicrobial properties (Kahkonen et al. 1999 Rauha et al. 2000 Puupponen-Pimia et al. 2001). Components of raspberry leaf extract exhibited relaxant activity in an in vitro gastrointestinal tissue (Rojas-Vera et al. 2002). 

Sulpiride, XXI, has been introduced in Europe and has been reported tg be a clinically important new class f neuroleptic agent ° with strong anti-emetic properties. In mice no emticonvulsant activity was noted. 

The unusual combination of release and antagonism of noradrenaline has been noted above, while another property separating oxypertine from other major tranquillizers is that it does not potentiate the analgesia produced by morphine or pethidine [161]. The compound is anti-emetic and weakly antihistaminic [160-2]. 

The prototype antihistamine of this group is diphenhydramine. It has antimuscarinic and pronounced central sedative properties and also an antitussive effect. The mechanism of the latter is unclear, but diphenhydramine is a common ingredient of propriety preparations for the treatment of coughs and colds. It is an effective anti-emetic, especially useful for prevention and treatment of motion sickness. Because of its anticholinergic properties it is occasionally used in the treatment of mild forms of Parkinson s disease. It is also of use in the treatment of drug-induced extrapyramidal effects. Piperazine derivatives... 

Cyclizine has antimuscarinic properties and is a potent anti-emetic, effective for the control of postoperative and drug-induced nausea and vomiting. It has been used to prevent motion sickness, although diphenhydramine and promethazine are more effective. It is available in oral and parenteral formulations. In contrast to many other first-generation antihistamines sedation is not marked. It is available in tablet form as the hydrochloride and in injectable form as the lactate. Because of its anticholinergic action, blurred vision and dry mouth are associated with clinical doses. When given by rapid intravenous injection tachycardia may be a problem. Meclozine is a related drug which, like cyclizine, is used primarily for motion sickness. 

J. Puffin and P. Rend, Antimoine Anti-biotique The public fortunes of the secret properties of antimony potassium tartrate (tartar emetic) , J. Hist. Med., 1991, 46, 44(M56. 

Rubiaceae, such as Cephaelis acuminata, Cephalis ipecacuanha, or Cephaelis accuminata. Ipecac alkaloids have powerful emetic and expectorant properties as well as anti-amoebic and antitumor activity, and some of them are widely used to treat amoebic dysentery (e.g., emetine and tubulosine), as well as schistosomiasis, leishmaniasis, and malaria (e.g., emetine). Isoquinoline alkaloid crispine A exhibits cytotoxic activity against SKOV3, KB, and HeLa human cancer lines and was isolated from C. crispus by Zhao et al. ... 

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