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Animal studies primates

Azmitia, E.C., and Gannon, P.J. The primate serotonergic system A review of human and animal studies and a report on Macaca fascicularis. [Pg.296]

Animal studies support he human evidence of neurobehavioral toxicity from prenatal exposure to low levels of lead. In an extensive review of the literature, Davis et al. (1990) discussed similarities between human effects and those in animals. The authors concluded that qualitatively "... the greatest similarities between human and animal effects involve cognitive and relatively complex behavioral processes such as learning." They further reported that quantitative relationships for PbB levels across species that cause developmental neurobehavioral effects are 10-15 pg/dL in children, <15 pg/dL in primates, and <20 pg/dL in rodents. [Pg.300]

Studies in animals and primates with these highly selective delta agonists begin to reveal that unlike mu opioid agonists such as morphine, oxy-contin, fentanyl, etc., agents acting at the delta receptor are unlikely to produce addictive liability and respiratory depression. In fact, delta agonists may actually counteract those side effects induced by mu opioids. [Pg.510]

Although animal studies indicate transfer of A -THC into the milk, comparable research has not been done on humans. It is difficult to extrapolate from animal studies to humans. The only primates studied, squirrel monkeys, are known to metabolize A9-THC differently than humans. (15) In addition, lactating human mothers in the general population ingest both A9-THC and other cannabinoids (e.g., CBN, CBD) by smoking cannabis. Information is not currently available regarding either transfer of cannabinoids into the milk of lactating humans or the effects of maternal cannabis use on infant development. [Pg.134]

I can find no evidence that follow-up studies were done to further evaluate Prozac-induced agitation or aggression in animals. No primates were tested for behavioral effects. [Pg.391]

The limitations of the primate or cat models of human HIV-1 CNS infection include the costs, special facility requirements, the necessity of using mixtures of viral strains (in order to develop reproducible CNS infection), and the relatively small numbers of animals studied that preclude meaningful statistical analyses. These obstacles have urged researchers to develop small animal models. Several rodent models were established including transgenic mice (expressing viral proteins or relevant inflammatory factors seen in HAD), mice infected primarily with murine retroviruses, or severe combined immunodeficient (SCID) mice inoculated intracerebrally with human HIV-1 infected macrophages and reconstituted with human peripheral blood lymphocytes (PBL). [Pg.304]

There are sufficient data to characterize the acute and chronic toxicity of propylene glycol in laboratory animals, including nonhuman primates. In humans, information on toxicity is limited to medical case studies. However, because of the similarities in the toxicokinetic profile of propylene glycol across species, the toxicity data from the animal studies can be extrapolated to human exposures. [Pg.2130]

Of particular importance is the collection of pharmacokinetic data showing the relationship between low-level exposure (acute, intermediate, and chronic) and blood and urine levels throughout the study. duration. Also tissue levels at necropsy should be taken immediately after cessation of dosing. In animal studies, a similar group of animals should be followed for urine (and blood, but not as important here) mercury levels for periods of 30, 60, 90, and 120 days postdosing to examine whole-body excretion, and necropsy tissue samples should also be taken from several animals at 30, 60, 90, and 120 days postdosing. Primates would be the best animal model, but rodent models could suffice. [Pg.384]

The rcspiratoiy tract, especially the upper respiratory tract, is a critical target of the toxicity of airborne formaldehyde as shown by acute controlled exposure human studies, by studies of humans exposed acutely or repeatedly under occupational or residential conditions, and by studies of animals (including primates) exposed by inhalation for acute, intermediate, and chronic durations. [Pg.61]


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See also in sourсe #XX -- [ Pg.351 ]




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