Serotonergic system

Chaouloff, F (1993) Physiopharmacological interactions between stress hormones and central serotonergic systems. Brain Res. 18 1-32. 

More fascinating was the response of the serotonergic system to MT and METH. When DA synthesis was interrupted by concurrent administration of MT, TPH activity remained normal after METH however, when DA synthesis was reinstated by administering eoneurrently /-dopa, a peripheral... 

These experiments provide evidence that DA and/or its reactive metabolites are likely involved in MDMA-induced changes in the serotonergic system. When DA synthesis was inhibited with MT, or when DA innervation was interrupted by 6-OHDA lesions, the effects of MDMA were prevented or attenuated. Depletion of DA with reserpine, or inhibition of DA uptake with GBR 12909, also attenuated the effects of MDMA on the serotonergic system. 

Johnson, M. Stone, D.M. Hanson, G.R. and Gibb, J.W. Role of dopaminergic nigrostriatal pathway in methamphetamine-induced depression of the neostriatal serotonergic system. Eur J Pharmacol 135 231-234, 1987. 

Peat, M.A. Warren, P.F. Bakhit, C. and Gibb, J.W. The acute effects of methamphetamine, amphetamine and p-chloroamphetamine on the cortical serotonergic system of the rat brain Evidence for differences in the effects of methamphetamine and amphetamine. Eur J Pharmacol 116 11-16, 1985. 

FIGURE 8. Comparison of the optical enantiomers of MDMA for the acute (3 hours) and long-term (7 days) effects on the serotonergic system... 

Pharmacologic Profile of Amphetamine Derivatives at Various Brain Recognition Sites Selective Effects on Serotonergic Systems... 

In addition to the aetions of MDMA and other derivatives at 5-HT2 serotonin reeeptors. some of the effeets on serotonergic systems could be mediated via S-HTja reeeptors, at whieh MDMA has a moderate affinity. Direct agonist effects at this site might eontribute to the mood-altering and calming effects of the drug, sinee similar effects have been reported for novel anxiolyties sueh as ipsaperone and buspirone, which interact with 5-HTia serotonin reeeptors. 

ANSWER When we are dealing with the effects of the methylenedioxy-substituted derivatives on serotonergic systems, we are dealing with a multiplicity of effects. 

Azmitia, E.C., and Gannon, P.J. The primate serotonergic system A review of human and animal studies and a report on Macaca fascicularis. 

Abrams, J. K., Johnson, P. L., Hay-Schmidt, A. et al. (2005). Serotonergic systems associated with arousal and vigilance behaviors following administration of anxiogenic drugs. Neuroscience 133, 983-97. 

Morin, L. P. 8r Meyer-Bernstein, E. L. (1999). The ascending serotonergic system in the hamster Comparison with projections of the dorsal and median raphe nuclei. Neuroscience 91, 81-105. 

Battaglia, G. and De Souza, E.B., Pharmacologic profile of amphetamine derivatives at various brain recognition sites selective effects on serotonergic systems, NIDA Res. Monogr. 94, 240-258, 1989. 

These differences may be extremely important in understanding the role of these two distinct serotonergic systems, arising from the dorsal and median raphe nuclei, in normal brain function and in mental illness. 

The serotonergic system has long been thought to play a role in major depression and bipolar disorders, although the exact mechanisms are yet to be determined 889... 

There is evidence for the contribution of serotonin dysfunction to mania, and in the mechanism of action of mood stabilizers [19], however, specific data on the serotonergic system and mania are fewer and variable. Moreover, altered functioning of other neurotransmitters in mania such as norepinephrine, dopamine, acetylcholine, and GABA, and their interaction with serotonin, are also likely to be involved in the pathogenesis of mood disorders. Differences in these neurotransmitter systems possibly underlie differences in the pathogenesis of depressive and manic episodes. 

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