2.3- -aniline acetate

Coe et al. reported an efficient modification for the preparation of /-substituted indole analogs for biology screening in good yield. The intermediate P-nitrostyrene 44, prepared from the condensation of 43 with DMFDMA, underwent methanolysis and reduction to provide the aniline acetal intermediate 45. Alkylation of amine 45 was carried out employing standard conditions of reductive alkylation to provide A-alkyl analogs represented by 46. The indole 47 was generated by formation of the oxonium ion (from 46) under acidic conditions, followed by cyclization, accompanied by loss of methanol. 

Aniline is very easily sulphonated, for example, by heating its sulphate ( baking process). This change recalls that of aniline acetate into acetanilide. Actually, it is very probable that an analogous product acylated at the amino-group, a sulphaminic acid, is first formed, since examples of this type of change are known, e.g. the conversion of phenylhydroxylamine to p-aminophenol and of phenylnitramine to... 

Furfural gives two characteristic colour reactions which serve for qualitative detection. With phloroglucinol and hydrochloric acid (1 part concentrated acid, 1 part water) a cherry-red colour is produced on boiling with a solution of aniline acetate a red colour is produced even in the cold. 

As long ago as 1896 Walther [43] observed that as the result of chemical reaction between ethyl nitrate and phenylhydrazine at an elevated temperature, aniline, ammonium nitrate and nitrogen are formed. If the reaction takes place in the presence of sodium ethoxide then, according to Bamberger and Billeter [44] even at room temperature nitrite ions, nitrogen, benzene, phenyl azide, azobenzene, nitrobenzene, aniline, acetic acid and acetaldehyde are formed. 

This reaction is extremely sensitive, freshly distilled pure aniline should be used and the acetic acid should be pure and should not give the furfural reaction Spirits which have been stored in wooden casks give with aniline acetate a yellow coloration which disturbs the reaction, in such cases the spirit should be distilled before testing... 

The following table contains data for aniline-acetate, which confirm this results The hydrolyzed fraction, as determined by the conductivity, is given under s, while V is the volume in litres containing one gram-molecule of aniline-acetate ... 

The determinations for, e.g., aniline acetate Zeitschr, /. Fhys. Chm, 5. 16) are, however, not favourable to this view. 

Finally, for salts like aniline acetate (p. 130), with both acid and base weak,... 

L. Robert. Compi. rend. 234, 2066-7 (1952). Adsorption ethanol, aniline, acetic acid on SiOa. 

The steps shown by rate coefficients are fast compared to the others. This is evident from the effect of solvent basicity upon the rate of rearrangement. Similar rate coefficients were obtained in the presence of diphenyl ether, dimethyl aniline, acetic acid or with neat solutions . The kinetic isotope effect data given in Table 24 provides additional support for the fact that k is high compared to the other rate coefficients. 

Less satisfactory preparations are (1) Mercuration of aniline acetate with mercuric oxide, (2) from N-mercuri-aniline,... 

Pentoses have frequently been determined in soils by the furfural-phloro-glucinol method.But phloroglucinol also gives precipitates with a variety of other aldehydes, such as 5-methyl-2-furaldehyde, 5-(hydroxymethyl)-2-furaldehyde, and formaldehyde. Orcinol and aniline acetate are much more specific reagents, and no aldehyde present in the hydrochloric acid distillate from soils has been found to interfere in the furfural determination by the orcinol method. The orcinol and aniline acetate methods give, for various Swiss and Norwegian soils, a pentose anhydride content of 0.5 to 8.5 % of the soil organic matter (see Table III) no corrections were made for the furfural derived from uronic acids. 

A iiwre expoflitious volumetric method is given by Powell and Whittaker. 0 5 to 0 8 g. of material is distilled with 12 per cent hydroehlorie aeid until tlie distillate gives no more pink colour with aniline acetate. The apparatus used for the distillation should have all-glass connections. Into each of four well-stoppered bottles is... 

The pellet is redissolved in 20 pi aniline/acetic acid solution and incubated for 20 min at 60°C in the dark. 

Aniline acetic acid (1.0 M aniline solution)c Mix first... 

Aniline acetate reaction The solid sample is heated over a flame, and the vapors are allowed to react with aniline acetate impregnated on a filter paper placed on the vapors. A red color will appear in presence of heterocyclic aldehydes produced from carbohydrate dehydration. 

GC-MS the modifier identity is more important than modifier concentration for enhancing extraction efficiencies of PAHs and PCBs however, the concentration influences over high molecular weight PAHs recoveries PCBs best modifiers acidic/basic modifiers including methanol, acetic acid and aniline low molecular weight PAHs best modifiers aniline, acetic acid, acetonitrile, methanol/toluene, hexane and diethylamine high molecular weight PAHs best modifiers toluene, diethylamine and methylene chloride Determination Online SFE-LC-UV extraction recovery 237... 

EXPLOSION and FIRE CONCERNS flammable liquid NFPA rating Health 4, Flammability 3, Reactivity 3 vapors are heavier than air and may travel to an ignition source and flashback dangerous fire and explosion hazard when exposed to heat, flame or oxidizers violent reaction with acids, aluminum chloride and substituted anilines, acetic acids, acetic anhydride, acrolein, acrylic acid, allyl chloride, chlorosulfonic acid, epichlorohydrin, hydrogen... 

It is usually prepared by boiling for some hours aniline acetate, which is formed by mixing aniline and acetic acid —... 

Method-I). It is prepared from aniline, acetic anhydride, sodium acetate and concentrated hydrochloric acid (12 N). 

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