History of Drug Discovery and Development

Cisplatin, (ds-[PtCl2(NH3)2], also known as cis-DDP) ((1), Figure 2) is perhaps the best known example of a small molecule metal-containing drug. The clinically used platinum complexes are shown in Figure 2. The history of the discovery and development of cisplatin remains a remarkable scientific story.33 Its use and effectiveness in cancer chemotherapy since the entry into the clinic in the late 1970s has been thoroughly documented.34-36 Cisplatin is cited for treatment of... 

The above brief history of early drug use and discovery is intended to be purely illustrative and the reader is referred to an excellent treatise by Mann 1 to become well informed on the history of drug use and development from the earliest historic times to the present day. 

History of the discovery and development of the drug in the country of origin and in Japan. 

Selassie C, Verma RP (2010) History of quantitative structure-activity relationships. In Abraham D (ed) Burger s medicinal chemistry, drug discovery and development. Wiley, New YotIc, pp 1—95... 

The 60-year history of antischistosomal drug discovery and development research in the People s Republic of China has been... 

It may be of some value to describe, briefly, the early history of the discovery of this class of anticancer drugs and the subsequent tortuous developments leading to its clinical use. 

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