High-Throughput Screening and Drug Discovery

Aslan, K., Holley, P., and Geddes, C. D. (2006). Microwave-Accelerated Metal-Enhanced Fluorescence (MAMEF) with silver colloids in 96-well plates Application to ultra fast and sensitive immunoassays. High Throughput Screening and drug discovery Journal of Immunological Methods-m-. 137-147. 

CHAPTER 7 High-Throughput Screening and Drug Discovery... 

Pozzan, A. Molecular descriptors and methods for ligand based virmal high throughput screening in drug discovery. Curr. Pharm. Des. 2006, 12, 2099-2110. 

After the hit discovery process (often using high-throughput screening), early drug discovery is generally split into a hit to lead phase and a lead optimization phase, followed by the selection of development candidates (DCs) (Figure 12.2). In vitro... 

Ch.M. Apfel and Th. Enderle, Assays for high throughput screening in drug discovery, in Combinatorial Chemistry - From Theory to Application, W. Bannwarth and B. Hinzen (eds), Wiley-VCH, Weinheim, 2005. 

However, the most important pharmaceutical use of robotics at present is in combinatorial chemistry in the search for new drugs. The impact of robotic high-throughput screening on drug discovery is a consequence of its ability to screen up to 100 000 samples per day per instrument this in turn results from the demand for new compounds — which is being met by combinatorial chemistry [91]. By way of example, a system based on a Zymark XP Zymate robot and a minimal modification of the chemical method of reaction assembly, execution and isolation of the products, allowed the synthesis... 

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