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Aqueous Solubility in Drug Discovery Chemistry, DMPK, and Biological Assays

Aqueous Solubility in Drug Discovery Chemistry, DMPK, and Biological Assays [Pg.9]

M + Protonated base or cationic counterion to conjugate base [Pg.9]

Solubility of a compound in its neutral form/intrinsic solubility [Pg.10]

Conjugate base or anionic counterion to protonated base [Pg.10]

Chapter 4. In this chapter, we will focus on the experimental aspect of aqueous solubility and its interplay in discovery chemistry, DMPK, and bioscience assays. Particular emphasis will be placed on the latest technologies for determining aqueous solubility and the use of the solubility data in different phases of drug discovery. [Pg.11]



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And drug discovery

Aqueous chemistry

Aqueous drug

Aqueous solubility and

Biologic drugs

Biological assays

Biological chemistry

Biological discoveries, chemistry

Biological discovery

Biological drugs

Biologies drug discovery

Chemistry and Biology

DMPK

Discovery solubility assay

Drug discovery aqueous solubility

Drug discovery assay)

Drug solubility

Drugs Soluble

In drug discovery

Solubility assay

Solubility, aqueous

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