Anaphylactic reaction immunoglobulin

The immune globulins are contraindicated in patients with a history of allergic reactions after administration of human immunoglobulin preparations and individuals with isolated immunoglobulin A (IgA) deficiency (individuals could have an anaphylactic reaction to subsequent administration of blood products that contain IgA). 

Allergenic activity. Fiber of the dried seed, administered orally to female adults, was active. Total serum immunoglobulin (Ig) E was elevated in a 40-year-old woman with allergic cutaneous and respiratory symptoms associated with chronic psyllium ingestion . Dried seedcoat, administered orally to adults, was active. A 60-year-old female suffered an anaphylactic reaction after ingestion of a psyllium-containing cereal f Skin prick result from psyllium powder and specific IgE antibodies were positive in a 31-year-old atopic woman who... 

Contraindications Previous history of anaphylactic reaction to egg protein, mouse immunoglobulin, or neomycin... 

Some reports suggest that anaphylaxis due to intravenous immunoglobulin infusion occurs most often in patients with primary hypogammaglobulinemia (115,116). However, anaphylactic reactions have been seen in two atopic patients with idiopathic thrombocytopenic purpura, and the authors warned that children with atopic disease should not receive intravenous immunoglobulin (117). 

Allergy a hypersensitivity of the immune apparatus s pathological immune reaction induced either by antibodies (immediate hypersensitivity) or by lymphoid cells (delayed type A.). Unlike the delayed type, immediate hypersensitivity can be passively transmitted in the serum. Symptoms of immediate hy-peisensitivity begin shortly after contact and decay rapidly, but delayed type symptoms do not attain a maximum for 24-48 hours then decline slowly over days or weeks Examples of immediate type A. are anaphylaxis the Arthus reaction and serum sickness. The best known A., anaphylaxia, can occur as a local (cutaneous) reaction (e.g. a rash with blisters) or as a systemic reaction (anaphylactic shock). Asthma, hay fever and nettle rashes are also examples of local anaphylactic reactions which are induced by reagins (see Immunoglobulins IgE). Only primates can be sensitized by injection with human reagins. An example of delayed type A. is the tuberculin reaction, which is based on a cellular immune response. 

Immunologic IgA-deficient patients with anti-IgA antibodies may form macromolec-ular complexes after administration of intravenous immunoglobulin, possibly leading to anaphylactic reactions. This can be prevented by using IgA-depleted intravenous immunoglobulin, even if it still contains a small amount of IgA [39 ]. Some adverse reactions can be associated with activation of the complement cascade, in which formation of IgG aggregates could play a role [fiC],... 

IX. PASSIVE CUTANEOUS ANAPHYLACTIC REACTIONS IN GUINEA PIGS MEDIATED BY HETEROLOGOUS IMMUNOGLOBULINS... 

Idiosyncratic dmg reactions (IDRs) are most commonly characterized by a reaction involving fever or rash, with or without internal organ involvement. The spectrum of responses ranges from a minor rash, to potentially fatal toxic epidermal necrosis and Stevens-Johnson syndrome. Immunoglobulin E (IgE)-mediated anaphylactic shock, occasional joint pain, hepatotoxicity or nephrotoxicity are also well documented [24]. The frequency of such reactions are unknown but estimated to be between 1 1000 and 1 10000 exposures and may be enhanced on re-challenging susceptible individuals with the same dmg. 

Passive immunity only lasts a short while and occurs when the mother passes protective agents such as immunoglobulins to the child in, for example, breast milk. Tetanus immunization is another example since it only lasts 10 years. The Rhesus response where the first child immunizes the mother against other children is also well known. Passive immunity also has the potential to produce undesirable immune responses such as allergic reactions or anaphylactic shock. 

Immunoglobulin E (IgE) bound to basophils or mast cells mediates immediate (anaphylactic-type) reactions. IgG or IgM antibodies also may be involved in allergic reactions, resulting in destruction of cells and tissues. 

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