Analytical 3.13. References

Reasonable grounds in support of tolerance petition Analytical reference standard(s)... 

EPA. 1984. Analytical reference standards and supplemental data The pesticides and industrial chemicals repository. EPA, Las Vegas, NV. EPA 600/4-84-082. October 1984. 

Chau ASY, Caeron J and Lee H-B (1979) Analytical reference materials. II. Preparation and sample integrity of homogeneous fortified wet sediment for polychlorinated hiphenyl quality control studies. J Assoc Off Anal Chem 62 1312-1314. 

Lee H-B and Chau ASY (1987) Analytical reference materials Part VII. development and certification of a sediment reference material for total polychlorinated biphenyls. Analyst 112 37-40. Meinke WW (1971) Standard reference materials for clinical measurements. Anal Chem 43(6) 28A-47A. 

Parr RM (1980) The reliability of trace element analysis as revealed by analytical reference materials. In Bratter P, Schramel P, eds. Trace Element Analytical Chemistry in Medicine and Biology, pp 631-655. Walter de Gruyter Co., New York. 

OPPTS 860.1560 Reasonable Grounds in Support of the Petition OPPTS 860.1650 Submittal of Analytical Reference Standards OPPTS 860.1850 Confined Accumulation in Rotational Crops OPPTS 860.1900 Field Accumulation in Rotational Crops. 

The ion-selective electrode-test solution (analyte)-reference electrode system is shown in the scheme... 

It is largely without debate that the term "reference substance" includes those chemical and biological materials that are used as standards in a study (i.e., those materials used for response comparison purposes, such as analytical reference standards). Normally, one thinks of reference substances as just referring to specimen (sometimes referred to as "matrix samples") analyses, but the characterization of test, control, and reference substances (see... 

Analyte Reference values/ umol/L Analytical results x Ax/(umol/L) Recovery Precision VrecOc) Trueness accCx) Comment The result is... 

One drawback of biocatalysis is that enzymes are not available in both enantiomeric forms. Particularly where a class of enzymes whose natural substrates are optically active, such as nucleosides, it can be difficult if not impossible to find an alternative enzyme that will accept the unnatural substrate enantiomer. This is not insurmountable if directed-evolution approaches are used, but it can be prohibitively expensive, especially when the desired product is in an early stage of development or required for use only as an analytical reference or standard. 

Layer Mobile Phase Visualization Analyte Reference... 

Column Detection Mobile phase Analytes Reference... 

Assuming NIR spectra have been recorded, once a set of pharmaceutical samples has been analyzed with high precision by some analytical reference method, the concentration of an analyte of interest clearly determined or the identity of a given... 

The National Analytical Reference Laboratory, now part of the NMI, was set up by Bernard King and then taken forward by Laurie Bezley. I am fortunate in chairing a committee that scrutinizes pure reference materials produced by the NMI and have worked fruitfully with organic chemists Steven Westwood and Stephen Davis. Thanks, too, to Lindsey MacKay, Adam Crawley, and many colleagues at NMI. 

The purity of the reference standard used to prepare spiked samples can affect the study data. For this reason, an analytical reference standard of known identity and purity should be used to prepare solutions of known concentrations. If possible, the reference standard should be identical to the analyte. When this is not possible, an established chemical form (free base or acid, salt, or ester) of known purity can be used. Three types of reference standards are generally used ... 

Analyte Reference Comments Matrix Technique Simplex mode ... 

In general see refs. 2-5. Selected crystallographic and analytical references are given where appropriate. Ln = lanthanide(III) or Ym ion. 

Thompson, J. F. Watts, R. R. "Analytical Reference Standards and Supplemental Data for Pesticides and Other Organic Compounds", EPA publication 60019-78-012, 1978. 

Custodian of analytical reference standards, receiving and cataloging incoming standards, discarding expired standards. 

Developing a plan to increase the available array of biomonitoringrelevant analytic reference materials (human samples containing chemicals at known concentrations appropriate for environmental or occupational medicine) the National Institute of Standards and Technology s Standard Reference Material Program is a useful model of such an activity. 

National Analytical Reference Laboratory, 1 Suakin Street, Pymble, NSW 2073, Australia... 

National Analytical Reference Laboratory, AGAL, Clive Road 3, Cottesloe,... 

On the other hand, the analyte or analyte reference standard may contribute to the response of an internal standard either due to impurity or because of natural abundance of stable isotopes (say m %). Therefore, the concentration of the internal standard must not be too low. Otherwise, the contribution from the analyte or its reference standard would be significant, e.g., more than 5 % of IS concentration or response [16], and linearity and accuracy could be greatly affected. Accordingly, a minimum IS concentration could be obtained based on the ULOQ for the analyte. For this reason, a high IS concentration is preferred. 

In-source transformation effects can only be perceived during method development if extracts of biological samples are analyzed under extended chromatographic runs. Interference by in-source transformation will not become evident if only spiked quality control materials are used which do not contain relevant metabolites. If one or more additional peak in the SRM trace of the target analyte is observed in comparison to analyte reference solutions, chromatography may only be accelerated to such degree that these peaks still remain baseline separated from the analyte. 

Unfortunately, sparteine is not marketed and approved for clinical use in many countries, including North America and the United Kingdom, and analytical reference compounds required for the GLC analytical procedure are not readily available. Accordingly, the use of sparteine for CYP2D6 phenotyping has had limited use outside a small number of mainly European investigators. 

Were analytical reference standards analyzed concurrently and... 

In the following, we list the requirements for the construction of an in-house NMR spectrum library for verification of CWC-related chemicals, and briefly describe the OCAD and the VERIFY database (VERIFTN s analytical reference database). 

VERIFY is a computerized database designed for the storage, management, and search of chemical and analytical reference data (44). Properties and contents of the NMR part of VERIFY are ... 

An analytical reference standard or working standard usually derived from a production batch is normally established as the comparative standard for routine analyses of the bulk drug substance for release purposes. It should be characterized against the primary standard. 

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