Anaesthetics halogenated volatile

Possible Role of Idiosyncrasy in Hepatitis Associated with Halogenated Volatile Anaesthetics... 

Hydrogen bond involving an acidic hydrogen atom borne by a fluorine-substituted or halogen-substituted carbon seems to contribute to the activity and the selectivity of volatile fluorinated anaesthetics (Table 2). These molecules, although non-functional, can bind stereoselectively with protein targets of the central nervous system [33,34]. 

Gases of interest are nitrous oxide and the inhalation vapours (or volatile halogenated anaesthetics) such as halothane (CF3CHBrCl), isoflurane (CHF2OCHCICF3) and enflurane (CHCIFCF2OCHF2). In this section electrochemical studies on nitrous oxide, halothane and isoflurane will be discussed. 

Isoflurane is more resistant to biotransformation in man than are other volatile halogenated anaesthetics [201,241,245] although there can be metabolic variations in different animal species [245], An average recovery of95 percent has been obtained in exhaled air, while post-operative urinary excretion of ionic and bound organic fluoride accounted for less than 0.2 per cent of the total fluorine dose [201]. In a separate study of 9 surgical patients, serum inorganic fluoride levels were 4.4 0.4 umol dm 6 h after anaesthesia [241 ]. 

Routine Direct Injection Gas-Liquid Chromatographic Procedure for the Analysis of Volatile Halogenated Anaesthetics in Whole Blood Using a New External Injection Port J. Chromatogr. 146(2) 297-310 (1978) CA 89 190684j... 

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