Possible Role of Idiosyncrasy in Hepatitis Associated with Halogenated Volatile Anaesthetics

Possible Role of Idiosyncrasy in Hepatitis Associated with Halogenated Volatile Anaesthetics 

Apart from the role of the metabolies as haptens, they may act as direct hepatic toxins. Idiosyncratic reactions due to the latter mechanism might be explained by the formation of an excess of toxic metabolites or normal amounts of abnormally toxic ones. For further reference the revies by Davis and Williams (1977), by Sherlock (1978) and by Cohen (1978) are recommended. 

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