Reactions to Other Halogenated Volatile Anaesthetics

Methoxyfluorane is another fluorinated compound which is structurally related to halothane, and which has also been reported to cause hepatic necrosis. The reaction produced closely mimics halothane-induced hepatitis. Furthermore crossreaction between these two compounds may occur (Judson et al. 1971). This is not surprising since they undergo similar metabolic processes. 

Other halogenated anaesthetics also rarely cause jaundice due to massive liver cell necrosis, but more frequently they cause subclinical hepatocellular damage as 

---