Ampicillin Chloroquine

Ampicillin sodium Amylobarbitone Betamethasone Betamethasone valerate Carbenicillin disodium Chloroquine phosphate Chloroquine sulphate Cemetidine Clofazimine Clofibrate Clonidine... 

Aletamine, alverine, ampicillin, atropine methobromide, atropine methonitrate, baclofen, benactyzine brown), bethanidine (-> brown), broxyquinoline, butanilicaine, chloroquine (100°), clidinium (-> brown), cyclandelate, cyclizine, dazomet, decoquinate (slow), diethylthiambutene (100°), dimefline, diuron, doxapram, dyclonine (100°), fenclofenac (100°— brown), fenitrothion, fenpipramide, glibenclamide (100°,... 

Orciprenaline Sulphate Trifluperidol Hydrochloride Ampicillin Sodium Disopyramide Phosphate Prednisolone Succinate Chloroquine Sulphate Guanoxan Sulphate Frusemide... 

Studies of chloroquine used in combination with antibiotics showed an antagonistic effect with penicillin but a synergistic effect with chlortetracycline. Urinary tests after single doses of ampicUhn 1 g and chloroquine 1 g showed a significant reduction in the systemic availability of the ampicillin. 

Clinically important, potentially hazardous interactions with acitretin, aldesleukin, aminoglycosides, amiodarone, amoxicillin, ampicillin, aspirin, bacampicillin, bismuth, carbenicillin, chloroquine, cisplatin, cloxacillin, co-trimoxazole, dapsone, demeclocycline, dexamethasone, diclofenac, dicloxacillin, etodolac, etoricoxib, etretinate, fenoprofen, flurbiprofen, folic acid antagonists, haloperidol, hydrocortisone, ibuprofen, indomethacin, influenza vaccines, ketoprofen, ketorolac, lithium, magnesium trisalicylate, meclofenamate, mefenamic acid, methicillin, mezlocillin, minocycline, nabumetone, nafcillin, naproxen, NSAIDs, omeprazole, oxacillin, oxaprozin, oxytetracycline, paromomycin, penicillin G, penicillin V, penicillins, phenylbutazone, piperacillin, piroxicam, polypeptide antibiotics, prednisolone, prednisone, probenecid, procarbazine, rofecoxib, salicylates, salsalate, sapropterin, sulfadiazine, sulfamethoxazole, sulfapyridine, sulfasalazine, sulfisoxazole, sulindac, tazobactum, tenoxicam, tetracycline, ticarcillin, tolmetin, trimethoprim, vaccines... 

Ampicillin, cefotaxime, ceftazidine, ciprofloxacin, methicillin, sulfathiazole, sulfamethoxazole Carbamazepine, felbamate, mesantoin, phenytoin, valproic acid Cimetidine, ranitidine Amodiaquin, chloroquine, quinine Chlorpromazine, clozapine, mianserin... 

A patient was given a 7-day course of metronidazole and ampicillin, following a laparoscopic investigation. She developed acute dystonic reactions (facial grimacing, coarse tremors, and an inability to maintain posture) on day 6, within 10 minutes of being given chloroquine phosphate (equivalent to 200 mg of base) and intramuscular promethazine... 

Chloroquine reduces the absorption of ampicillin, but bacampi-cillin is unaffected. 

Chloroquine 1 g reduced the absorption (as measured by excretion in the urine) of a single 1-g dose of oral ampicillin by about one-third (from 29 to 19%) in 7 healthy subjects. Another study by the same author demonstrated that the absorption of ampicillin from bacampicillin tablets was unaffected by chloroquine. ... 

A possible reason for the reduction in absorption is that the chloroquine irritates the gut so that the ampicillin is moved through more quickly, thereby reducing the time for absorption. 

Information appears to be limited to the studies cited, which used large doses of chloroquine (1 g) when compared with those usually used for malarial prophylaxis (300 mg base weekly) or for rheumatic diseases (150 mg daily). The reduction in the ampicillin absorption is also only moderate. The general clinical importance of this interaction is therefore uncertain. However, one report suggests separating the dosing by not less than 2 hours. An alternative would be to use bacampicillin (an ampicillin pro-drug), which does not appear to interact with chloroquine. More study is needed to confirm and evaluate the importance of this interaction. 

Ali HM. Reduced ampicillin bioavailability followii oml coadministration with chloroquine. 

Ali HM. The effect of Sudanese food and chloroquine on the bioavailability of ampicillin from bacampicillin tablets. IntJ Pharmaceutics (1981) 9,185-90. 

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