Amphetamine and Related Compounds

The drugs themselves can be totally synthetic, and indeed, precursor chemicals such as benzyl methyl ketone are subject to separate controls and monitoring. Alternatively, they may be semi-synthetic, where natural products have been used as the starting materials for the synthesis. There are a number of synthetic routes described in the literature [1, 2], in addition to a plethora of Internet sites where recipes are described. 

The drugs themselves are mixed with a wide variety of adulterants and diluants and also contain a cocktail of related products and impurities from the manufacturing process. These products can be used for drug comparison but the effects of these on the drug user are not fully understood and may be extremely harmful. 

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This really crazy looking method is one of them. There are a lot of things about it that make it very attractive. The first is the author of the article Rajender S. Varma. You will see in the Nitropropene section of this book (and in references from many other parts of the book) that this guy has been making a lot of strangely applicable advances in catalysis, amination, and reduction of amphetamines and related compounds. It is uncanny how often Strike has come across this person s work. It is like he is the Shulgin of basic precursor and amphetamine progress. Go figure ... 

Amphetamine and related compounds are indirect acting sympathomimetic agents that are frequently abused due to their stimulant properties on the central nervous system. Amphetamines act by inducing the... 

Huang, J.T., and Ho, B.T. Discriminative stimulus properties of d-amphetamine and related compounds in rats. Pharmacol Biochem Behav 2 569-673, 1974b. 

Jonsson, L., and Gunne, L. Clinical studies of amphetamine psychosis. In Costa, E., and Garattini, S., eds. Amphetamines and Related Compounds. New York Raven Press, 1970. ppi. 929-936. 

TABLE 1. Characteristics of monoaminergic neurotoxicity induced by amphetamine and related compounds in laboratory animals... 

Bowyer, J.F., Spuler, K.P., and Weiner, N., Effects of phencyclidine, amphetamine and related compounds on dopamine release from and uptake into striatal synaptosomes, J. Pharmacol. Exp. Ther., 229, 671, 1984. 

Huang, Y.S., Liu, J.T., Lin, L.C., and Lin, C.H., Chiral separation of 3,4-methylenedioxymeth-amphetamine and related compounds in clandestine tablets and urine samples by capillary electro-phoresis/fluorescence spectroscopy, Electrophoresis 24(6), 1097-1104, 2003. 

Hernandez R, Falco P, Cabeza A. 1997. Liquid chromatographic analysis of amphetamine and related compounds in urine using solid-phase extraction and 3,5-dinitrobenzoyl chloride for derivatization. J Chromatogr Sci 35(4) 169-175. 

HUl RT (1970) Facilitation of conditioned reinforcement as a mechanism of psychomotor stimulation. In Garattimi EGAS (ed) Amphetamines and related compounds. Raven, New York, pp 781-795... 

Amphetamine and related compounds (dexamphetamine, methylphenidate, ephedrine, MDMA [ecstasy], cocaine and other dopaminergic drugs)... 

Sympathomimetic drugs - amphetamines and related compounds, theophylline... 

Schiorring, E. (1977). Changes in individual and social behavior induced by amphetamine and related compounds in monkeys and man. In E. H. Ellinwood Jr. M. M. Kilbey (Eds.), Cocaine and other stimulants (pp. 481-522). New York Plenum. 

Wallenborg SR, Lurie IS, Arnold DW, Bailey CG. On-chip chiral and achiral separation of amphetamine and related compounds labeled with 4-fluoro-7-nitro-benzofurazane. Electrophoresis 2000 21 3257-3263. 

Snyder, S. H., Richelson, E., Weingartner, H. and Faillace, L. A. (1970). Psychotropic methoxy-amphetamines. Structure and activity in man. In Amphetamines and Related Compounds, E. Costa and S. Garratini (Eds.), Raven Press, New York, pp. 905-928. 

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