Floating dosage forms

Menon A, Ritschel A, Sakr A. Development and evaluation of a monolithic floating dosage form for furosemide. J Pharm Sci 1994 83 239-245. 

Goole J., F. Vanderbist, and K. Amighi (2006). Development and evaluation of new multiple-unit levodopa sustained-release floating dosage forms. International Journal of Pharmaceutics 334 35 1. 

Whitehead, L., et al. 1998. Floating dosage forms an in vivo study demonstrating prolonged gastric retention. J Control Release 55 3. 

Whitehead, L., J.H. Collet, and J.T. Fell. 2000. Amoxycillin release from a floating dosage form based on alginates. Int J Pharm 210 45. 

Hilton, A. K., and Deasy, P. B. In vitro and in vivo evaluation of an oral sustained-release floating dosage form of amoxycillin trihydrate. Int. J. Pharm. 86 79-88, 1992. 

Ozdemir, N., Sefika, 0., and Ozkan, Y. Studies of floating dosage forms of furosemide In vitro and in vivo evaluations of bilayer tablet formulations. Drug Dev. Ind. Pharm. 26 857-866, 2000. 

Fell, J. T., Whitehead, L., and Collett, J. H. Prolonged gastric retention Using floating dosage forms. Pharm. Tech. 24 82-89, 2000. 

In the case of hard-gelatin capsules and other floating dosage forms, a sinker is required to weight the sample down until it disintegrates and releases its contents at the bottom of the vessel. The sinker has to hold... 

Goole J, Vanderbist F, Amighi K. Development of new multiple-unit sustained-release floating dosage forms. Int J Pharm 2007 33 l-2) 35-41. 

Nakamichi, K. Yasuura, H. Fukui, H. Oka, M. Izumi, S. Evaluation of a floating dosage form of nicardipine hydrochloride and hydroxypropyhnethylcellulose acetate succinate prepared nsing a twin-screw extruder. Int. J. Pharm. 2001, 218(1-2), 103-112. 

Basket USP 1 EP basket JP method 1 BP 1 Rotating stirrer Dosage form confined leads to consistent solid/liquid interface Floating products kept immersed Limited sink conditions Trapped bubbles in basket can slow dissolution rate Inadequate mixing at slow speed Floating dosage forms Dosage forms that tend to adhere to the vessel surfaces... 

Paddle USP 2 EP paddle JP method 2 BP II Rotating stirrer Simple to use and automate Widely available Limited sink conditions Sinkers needed for floating dosage forms Coning can occur with large dosage forms Majority of solid dosage forms Suspensions... 

---