Amphetamine Phosphate

N-diben2yloxycarbonyl-p-oxy-dl-a -aminophen.ylacetamido)-penicillanic acid so liberated was extracted into diethyl ether (50 ml and 2 portions of 30 ml). The ether phase was washed with water (3 x 5 ml) and the water washings were discarded. 

Structural Formula C6H5CH2CH(NH2)CH3 H3P04 Chemical Abstracts Registry No. 139-10-6 

Trade Name Manufacturer Country Year Introduced 

1 mol of phenyl-nitropropylene, CaHsCH=C(CH3)N02, is dissolved with a solvent prepared by mixing one liter of ethanol with one-half liter of acetic acid and one-half liter of 12 N sulfuric acid. The resultant solution is placed in the cathode compartment of a divided electrolytic cell containing a metallic cathode of mercury, copper, or other metal of similar nature, Current Is passed, using a current density of 0.2 amp/cm of cathode surface. The temperature is kept at about 40°C during the electrolysis which Is continued until at least eight Faradays of electricity have been passed. 

When the reduction is completed, the 1-phenyl-2-aminopropane may be separated from the solution. A convenient way of doing this is by removing the ethanol and ethyl acetate present by evaporation and then making the residual solution strongly alkaline by addition of caustic alkali. The basic layer thus formed is separated from the aqueous solution and contains the desired 1-phenyl-2-amlnopropane. 

Finally, the penicillin was converted to the sodium salt by shaking the ether solution with sufficient 3% sodium bicarbonate to give a neutral aqueous phase, separating the latter and evaporating it at low pressure and temperature below 20 C. The product was finally dried over phosphorus pentoxide In vacuo to give sodium 6-(0,N-dibenzyloxycarbonyl-p-oxy-dl-a-aminophenylacetamido)-penicillanate (9.2 grams). 

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When the entire quantity of the phosphoric acid has thus been added, agitation of the mixture is continued for about a half-hour or more to insure complete conversion. The precipitate is then allowed to settle, the supernatant liquid is drawn off, and the residue is filtered. The precipitate thus separated may, if desired, be washed with acetone and is then dried by evaporation to constant weight. It forms a fine, white, impalpable powder consisting of pure monobasic amphetamine phosphate. 

Synonyms. Benzpropaminum Phosphoricum Monobasic Racemic Amphetamine Phosphate. 

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