Isocarboxazid Amitriptyline

Nakamura, M., Fukushima, H., and Kitagawa, S. (1976) Effect of amitriptyline and isocarboxazid on 5-hydroxytryptophan induced head twitches in mice. Psychopharmacology, 48 101-104. 

There are four classes of antidepressants tricyclic antidepressants (imipramine, trimipramine, amitriptyline, doxepin, desipramine, protriptyline, nortriptyline, amoxapine, maprotiline) monoaminooxidase (MAO) inhibitors (phenelzine, isocarboxazid, tranylcypromine) second-generation antidepressants or atypical antidepressants, which are a chemically dissimilar group of recently proposed drugs (bupropion, trazodone, fluoxetine) and amphetamines and other stimulators of the CNS (dextroamphetamine, methylphenidate). 

OFFICIAL NAMES Amitriptyline (Elavil), amoxapine (Asendin), bupropion (Wellbutrin), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), fluoxetine (Prozac), imipramine (Norfranil, Tofranil), isocarboxazid (Marplan), maprotiline (Ludiomil), mirtazapine (Remeron), nefazodone (Serzone), nortriptyline (Aventyl, Pamelor), paroxetine (Paxil), phenelzine (Nardil), protriptyline (Vivactil), sertraline (Zoloft), thioridazine (Mellaril), tranylcypromine (Parnate), trazodone (Desyrel), trimipramine (Sur-montil), venlafaxine (Effexor) the herb St. John s wort (Hypericum perforatum) is sold over-the-counter without prescription STREET NAMES Happy pills... 

Antidepressants MAO-I (e.g., isocarboxazid, phenelzine, tranylcypromine) Tricyclic antidepressants (e.g., amitriptyline, desipramine, nortriptyline, etc.)... 

Quazepam Venlafaxine Amitriptyline Selegiline (deprenyl) Lithium carbonate Lithium carbcxiate controlled release Triazolam Haloperidol Propranolol Clonazepam Chlordiazepoxide Lithium carbonate slow release Lithium carbonate Lithium carbonate Loxapine Maprotiline Fluvoxamine Isocarboxazid... 

Clinically important, potentially hazardous interactions with amitriptyline, amphetamines, aprepitant, astemizole, clarithromycin, dexibuprofen, dextroamphetamine, diethylpropion, digitalis, digoxin, duloxetine, erythromycin, isocarboxazid, linezolid, MAO inhibitors, mazindol, methamphetamine, molindone, phendimetrazine, phenelzine, phentermine, phenylpropanolamine, pseudoephedrine, risperidone, selegiline, sibutramine, St John s wort, sumatriptan, sympathomimetics, tranylcypromine, trazodone, troleandomycin... 

Antidepressants are divided into the following classes the dibenzapine derivatives are called tricyclic antidepressants and include imipramine (Tofranil), desipramine (Norpramin), amitriptyline (Elavil), nortriptyline (Aventyl), protriptyline (Vivactil), and doxepin (Adapin). The monoamine oxidase inhibitors are nsed occasionally to treat depression. The hydrazine derivatives consist of isocarboxazid (Marplan) and phenelzine sulfate (Nardil). The nonhydrazine derivatives inclnde tranylcypromine (Parnate). L-Tryptophan is the only member of the monoamine precnrsors nsed to treat depression. The newer and second-generation antidepressants inclnde amoxapine, doxepin, flnoxetine, maprotiline, trazodone, mianserin, alprazolam, and bnpropion (see also Tables 5 throngh 7). 

Three patients with bipolar disorder developed mania when treated with isocarboxazid and amitriptyline. ... 

In contrast, there are a number of other uncontrolled studies and reviews describing the beneficial use of an MAOI with a tricyclic antidepressant. In addition, one study has reported switching 178 patients from tricyclics to MAOIs within 4 days or less. Of these patients, 63 were given the MAOI while still being tapered from the tricyclic, all without any apparent problems. Nevertheless, in a 6-week randomised doubleblind trial, the combinations of phenelzine or isocarboxazid plus trimi-pramine were less effective than trimipramine alone in patients with mild to moderate depression. Similarly, in a smaller randomised open study, the combination of amitriptyline and tranylcypromine was no more effective than either drug alone. ... 

Tranylcypromine, phenelzine, clomipramine and imipramine appear to be high on the list of drugs that have interacted adversely. Combination of clomipramine with tranyleypromine is particularly dangerous. Amitriptyline, trimipramine and isocarboxazid are possibly safer. 

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