Maprotiline Fluvoxamine

Extracted amitriptyline, clomipramine, desipramine, doxepin, fluoxetine, fluvoxamine, maprotiline, protriptyline Interfering imipramine... 

Maprotiline, Moclobemide, Mianserin, Fluoxetine (Prozac), Paroxetine, Sertraline, Fluvoxamine, Citalopram, Venlafaxin (generic IR formulation and the brand Venlafaxine XR), Mirtazapine, Flupentixol-melitracen (Deanxit), Tianeptine, Extract of St. John s Wort, Buspirone Depression and anxiety... 

Note. BROF = brofaromine CIT = citalopram CLO = clomipramine CT = cognitive therapy Dx = diagnosis EXP = exposure in vivo FLU = fluvoxamine FLUOX = fluoxetine GAD = generalized anxiety disorder 5-HTP = 5-hydrox3rtryptophan IMl = imipramine MAP = maprotiline OCD = obsessive-compulsive disorder PAR = paroxetine PD = panic disorder PLA = placebo PPM = psychological panic management RIT = ritanserin ... 

Kasper S, Dotsch M, Vieira A, et al. Plasma concentration of fluvoxamine and maprotiline in major depression implications on therapeutic efficacy and side effects. Eur Neuropsychopharmacol... 

Imipramine, desipramine, amitriptyline, nortriptyline, trimipramine, clomipramine, lofepramine, amoxapine, dosulepin, maprotiline, mianserin, setiptiline, trazodone, fluvoxamine, paroxetine, milnacipram, sulpiride, tandspirone, methylpheni-date, melitracen Amitriptyline, imipramine, trimipramine, clomipramine, citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine, reboxetine, viloxazine, doxepin, maprotiline, mianserine, mirtazapine, moclobemide, trazodone, opipramol (and some metabolites)... 

In a systematic review of 32 randomized trials in which 1389 patients took lithium and 2069 took another agent (carbamazepine, divalproex, lamotrigine, or the antidepressants amitriptyline, fluvoxamine, mianserin, and maprotiline), among the seven studies that reported suicides, lithium-treated patients had significantly fewer completed events (242). These included two suicides on lithium (out of 503, 0.4%) and 11 suicides on other agents (two placebo, two amitriptyline, six carbamazepine, and one lamotrigine, out of a total of 601,1.8%) (OR = 0.26 95% Cl = 0.09, 0.77). 

Quazepam Venlafaxine Amitriptyline Selegiline (deprenyl) Lithium carbonate Lithium carbcxiate controlled release Triazolam Haloperidol Propranolol Clonazepam Chlordiazepoxide Lithium carbonate slow release Lithium carbonate Lithium carbonate Loxapine Maprotiline Fluvoxamine Isocarboxazid... 

Extracted metabolites, desipramine, fluvoxamine, imipramine, maprotiline, nortriptyline Noninterfering chlordiazepoxide, clobazam, clozapine, diazepam, flurazepam, fluspiri-lene, haloperidol, nitrazepam, oxazepam, perazine, pimozide, spiroperidol, trifluperidol Interfering clomipramine, doxepin... 

Simultaneous clozapine, desipramine, doxepin, fluvoxamine, imipramine, maprotiline, metoclopramide, norfluoxetine, nortriptyline... 

Joron, S. Robert, H. Simultaneous determination of antidepressant drugs and metabolites by HPLC. Design and validation of a simple and reliable analytical procedure. Biomed.Chromatogr., 1994, 8, 158-164 [simultaneous amineptine, amitriptyline, amoxapine, clomipramine, demexiptiline, desipramine, dosulepine, doxepin, doxepine, fluvoxamine, imipramine, maprotiline, medifloxamine, mianserine, opipramol, quinupramine, tianeptine, toloxatone, trazodone, trimipramine, viloxazine LOQ 3-17 ng/mL plasma]... 

Thomare, R Wang, K. Van Der Meersch-Mougeot, V. Diquet, B. Sensitive micromethod for column liquid chromatographic determination of fluoxetine and norfluoxetine in human plasma. J.Chromatogr., 1992, 583, 217-221 [plasma extracted metabolites LOD 2 ng/mL simultaneous amineptine, amitriptyline, chlordiazepoxide, chlorpromazine, clomipramine, clonazepam, clorazepate, desipramine, diazepam, doxepin, flunitrazepam, fluvoxamine, imipramine, levomepromazine, loraze-pam, loxapine, maprotiline, mefloquine, nortriptyline, oxazepam, thioridazine]... 

Fluvoxamine inhibits the cytochrome P450 liver catabolic enzymes (predominantly this is inhibition of N-demethylation), leading to an increase in tricyclic antidepressant (TCA) serum levels. Plasma levels of several antidepressant drugs (e.g. amitriptyline, clomipramine, desipramine, imipramine, maprotiline, and nortriptyline) have been reported to increase by up to 4-fold during co-administration with fluvoxamine. Fluvoxamine at a daily dose of 50-100 mg causes a 3-4-fold increase in the plasma concentration of mirtazapine. 

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