Interstitial nephritis 5-aminosalicylic acid

Laboudi A, Makdassi R, Cordonnier C, Fournier A, Choukroun G. Nephrite interstitielle chronique au 5-ASA mise au point a partir d un nouveau cas. [Chronic interstitial nephritis induced by 5-aminosalicylic acid a new case report.] Nephrologie 2002 23(7) 343-7. 

De Broe ME, Stolear JC, Nouwen EJ, Elseviers MM. 5-Aminosalicylic acid (5-ASA) and chronic tubulo-interstitial nephritis in patients with chronic inflammatory bowel disease is there a link Nephrol Dial Transplant 1997 12 1839-1841. 

Henning HV, Mein hold J. Chronische interstitielle nephritis durch 5-aminosaiicyisaure Deutsch Med Wsch 1989 114 1091. Ruf-BallaufW, Hofstadter F, Krentz K. Acute interstitielle nephritis durch 5-aminosaiicyisaure internist 1989 30 262-264. Mehta RP. Acute interstitial nephritis due to 5-aminosalicylic acid. Can Med Assoc J1990 143(10) 1031-1032. 

Lithium, cyclosporine, and only a few other drugs have been reported to cause chronic interstitial nephritis, which is usually a progressive and irreversible lesion. Streptozotocin and other antineoplastic nitrosoureas also cause dose-dependent chronic interstitial disease. In addition, mesalazine, 5-aminosalicylic acid, and ifosfamide may cause chronic interstitial nephritis, which usually resolves promptly when drug use is discontinued. 

Observational studies Mesalazine (mesala-mine, 5-aminosalicylic acid) has been linked with tubulointerstitial nephritis in patients with inflammatory bowel disease. In a retrospective analysis of renal impairment during long-term use of aminosalicylates in 171 patients with inflammatory bowel disease, the mean daily dose was 3.65 g/day and the mean treatment duration 8.4 years treatments included mesalazine (74%), sulfasalazine (15%), and the combination (11%) [87 ]. Serum creatinine concentrations increased significantly during treatment, from 77 to 89 pmol/1, and creatinine clearance fell significantly from 105 to 93 ml/minute. The fall in creatinine clearance correlated positively with the mean daily dose. There was one case of interstitial nephritis. 

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