Aminosalicylic acid, calcium salt

Aminosalicylic acid and its salts have been used in the treatment of tuberculosis, Aminosalicylic acid can be prepared by the carboxylation of m- am in oph en o1 (32). Aminosalicylic acid USP assays not less than 98.5% and not more than 100.5%, calculated on the anhydrous basis. The antitubercular agents are likely to be used as the more tolerated salts calcium [133-15-3] potassium [133-09-5] sodium [133-10-8] and the ethyl [6069-17-2] and phenyl [133-11-9] esters of -aminosalicylic acid. 

In general, aromatic primary amino moiety (i.e., Ar-NH2), as present in a host of sulphadrugs viz., succinyl sulphathiazole, sulphamethoxazole, sulphaphenazole and other potent pharmaceutical substances, for instance sodium or calcium aminosalicylate, isocarboxazid, primaquine phosphate, procainamide hydrochloride, procaine hydrochloride and dapsone react with sodium nitrite in an acidic medium to yield the corresponding diazonium salts as expressed below ... 

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