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Aminophylline. consider

For many years oral xanthines, shown in Table 2, were the preferred first-line treatment for asthma in the United States, and if the aerosol and oral formulations of P2" go sts are considered separately, as they are in Table 1, this was still the case in 1989. Within this class of compounds theophylline (8), or one of its various salt forms, such as aminophylline [317-34-0] (theophylline ethylenediamine 2 l), have been the predominant agents. Theophylline, 1,3-dimethylxanthine [58-55-9], is but one member of a class of naturally occurring alkaloids. Two more common alkaloids are theobromine (9), isomeric with theophylline and the principal alkaloid in cacao beans, and caffeine, (10), 1,3,7-Trimethylxanthine [58-08-2], found in coffee and tea. [Pg.440]

Treat bronchospasm with a -agonist given intermittently or continuously, consider the use of aminophylline 5.6 mg/kg as an IV loading dose, given over 20 minutes, or to maintain a blood level of 8— 15 mcg/mL... [Pg.966]

Airway. Ensure a patent airway via endotracheal intubation or cricothyrotomy (ie, inferior laryngotomy, used prior to tracheotomy) and administer oxygen. Severe respiratory difficulty may respond to IV aminophylline or to other bronchodilators. Hypotension The patient should be recumbent with feet elevated. Depending upon the severity, consider the following measures ... [Pg.2115]

A variety of drugs in distinct pharmacological and chemical classes can be considered under the broad classification as stimulants. Xanthines and methylxan-thines constitute a weak class of stimulants that includes caffeine, theophylline (aminophylline),and theobromine. Caffeine is freely available in coffee, colas, and certain over-the-counter pills. A low degree of tolerance develops to some of their effects and a mild withdrawal syndrome is observed following immediate cessation of their repeated use. [Pg.410]

Aminophylline sometimes aggravates bronchial asthma sensitization to the ethylenediamine component is considered to be responsible (SEDA-6, 5). [Pg.3362]

These cases of interactions of aminophylline with macro-lide antibiotics illustrate that serious, even fatal, adverse effects can occur when possible interactions are not considered. In both cases, experienced physicians prescribed appropriate antimicrobial drugs, but omitted to consider the possibility of interactions with aminophylline, and failed to reduce the dose of aminophyUme or to measure theophylline concentrations. In the first case the development of tachycardia, hypokalemia, acidosis, vomiting, and convulsions can be explained on the basis of theophylline toxicity caused by ciprofloxacin, while in the second the anxiety, tremor, and cardiac arrests could all have resulted from an interaction of aminophylline and erythromycin. These cases add to an extensive literature that emphasizes the potential for interaction between aminophylline and drugs metabolized by CYP1A2. [Pg.3367]

Although asthma is considered to be a reversible condition, severe acute attacks can cause obstruction that can take days to reverse and in some cases is not reversible at all. Such attacks need to be treated as a medical emergency requiring hospital treatment. Treatment includes oxygen, inhalation of salbutamol in oxygen, intravenous hydrocortisone and oral prednisolone. Sometimes inhaled antimuscarinics are also used and intravenous salbutamol and aminophylline plus antibiotics if there is infection as well. [Pg.92]


See other pages where Aminophylline. consider is mentioned: [Pg.150]    [Pg.152]    [Pg.153]    [Pg.153]    [Pg.518]    [Pg.548]    [Pg.9]    [Pg.106]    [Pg.244]    [Pg.1171]    [Pg.235]    [Pg.59]    [Pg.189]   


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Aminophylline

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