Aminobutyric Acid Receptors

Enna, S. J., and Snyder, S. H., 1977, Influences of ions, enzymes, and detergents on 7-aminobutyric acid receptor binding in synaptic membranes of rat brain. Mol. Pharmacol. 13 442-453. [Pg.92]

Miller LG, Greenblatt DJ, Roy RB, et al Chronic benzodiazepine administration, II discontinuation syndrome is associated with upregulation of gamma-aminobutyric acid receptor complex binding and function. J Pharmacol Exp Ther 246 177-182, 1988b... [Pg.157]

Corrigall WA et al. Response of nicotine self-administration in the rat to manipulations of mu-opioid and gamma-aminobutyric acid receptors in the ventral tegmental area. Psychopharmacology 2000 149(2) 107-114. [Pg.459]

The aforementioned polymer-supported bis-pyridyl ligand has also been applied in microwave-assisted asymmetric allylic alkylation [140], a key step in the enantio-selective synthesis of (R)-baclofen (Scheme 7.118), as reported by Moberg and coworkers. The ( (-enantiomer is a useful agonist of the GABAb (y-aminobutyric acid) receptor, and the racemic form is used as a muscle relaxant (antispasmodic). Under microwave heating, the enantioselectivity could be improved to 89% when using toluene as solvent (see also Scheme 6.52) [140],... [Pg.376]

M. (1995) Deficiency of the P3 subunit of the type A y-aminobutyric acid receptor causes cleft palate in mice. Nature Genetics 11, 344-346. [Pg.109]

Chan-Palay, V. (1978) Autoradiographic localization of y-aminobutyric acid receptors in the rat central nervous system by using (3H)muscimol. Proc. Natl. Acad. Sci. USA, 75 1024-1028. [Pg.89]

Abalis IM, Eldefrawi AT, Eldefrawi ME (1986) Actions of avermectin Bla on the gamma-aminobutyric acid receptor and chloride channels in rat brain. J Biochem Toxicol 1 69-82... [Pg.72]

DE GAMMA-AMINOBUTYRIC-ACID RECEPTOR PI SUBUNIT PRECURSOR (GABA(A)... [Pg.62]

GABRP Gamma-aminobutyric acid receptor pi subunit... [Pg.259]

Boileau AJ, Kucken AM, Evers AR, Czajkowski C. 1998. Molecular dissection of benzodiazepine binding and allosteric coupling using chimeric y-aminobutyric acid receptor subunits. Mol Pharmacol 53 295. [Pg.438]

Abalis IM, Eldefrawi ME, Eldefrawi AT. 1985. High-affinity stereospecific binding of cyclodiene insecticides and y-hexachlorocyclohexane to y-aminobutyric acid receptors of rat brain. Pestic Biochem Physiol 24 95-102. [Pg.129]

Cui Y, Rajasethupathy P, Hess GP (2004) Selecrion of stable RNA molecules that can regulate the channel-opening equilibrium of the membrane-bound gamma-aminobutyric acid receptor. Biochemistry 43 16442-16449... [Pg.38]

Mectianism of Action An antidote that antagonizes the effect of benzodiazepines on the gamma-aminobutyric acid receptor complex in the CNS. Therapeutic Effect Reverses sedative effect of benzodiazepines. [Pg.507]

Majewska MD, Schwartz RD Pregnenolone-sulfate an endogenous antagonist of the y-aminobutyric acid receptor complex in brain Brain Res 404 355-360, 1987 Majewska MD, Harrison NL, Schwartz RD, et al Steroid hormone metabolites are barbiturate-hke modulators of the GABAa receptor. Science 232 1004-1007, 1986... [Pg.688]

Susdak PD, Schwartz RD, Scolnick P, et al Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes. Proc Natl Acad Sci U S A 83 4071-4075, 1986... [Pg.753]

W Chen, M Terada, JT Cheng. Characterization of subtypes of gamma-aminobutyric acid receptors in an Ascaris muscle preparation by binding assay and binding of PF1022A, a new anthelmintic, on the receptors. Parasitol Res 82 97-101, 1996. [Pg.495]

Kuriyama, T., Schmidt, T.J., Okuyama, E. and Ozoe, Y. (2002) Structure-activity relationships of seco-prezizaane terpenoids in gamma-aminobutyric acid receptors of houseflies and rats. Bioorganic and Medicinal Chemistry 1 0(6), 1 873-1 881. [Pg.329]

Casida JE, Tomozawa M (2008) Insecticide Interaction with y-Aminobutyric Acid and Nicotinic Receptors Predictive Aspects of Stractural Models. J Pestic Sci 33 4 Chen LG, Durkin KA, Casida JE (2006) Stractural Model for y-Aminobutyric Acid Receptor Noncompetitive Antagonist Binding Widely Diverse Structures Fit the Same Site. Proc Nat Acad Sci USA 103 5185... [Pg.209]

Zheng W, Xie W, Zhang J, Strong JA, Wang L, Yu L, Xu M, Lu L (2003) Function of gamma-aminobutyric acid receptor/channel rho 1 subunits in spinal cord. J Biol Chem 278 48321-48329... [Pg.535]

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