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Pregnenolone sulfate

Wang MD, Wahlstrom G, Backstrom T. 1997. The regional brain distribution of the neurosteroids pregnenolone and pregnenolone sulfate following intravenous infusion. J Steroid Biochem Mol Biol 62(4) 299-306. [Pg.42]

Takase M, Ukena K, Yamazaki T, Kominami S, Tsutsui K. 1999. Pregnenolone, pregnenolone sulfate, and cytochrome P450 side-chain cleavage enzyme in the amphibian brain and their seasonal changes. Endocrinology 140 1936-1944. [Pg.90]

The neurosteroid pregnenolone sulfate infused into the medial septum nucleus increases hippocampal acetylcholine and spatial memory in rats. Brain Research 951(2) 237-242. [Pg.244]

Pallares M, Darnaudery M, Day J, Le Moal M, Mayo W. 1998. The neurosteroid pregnenolone sulfate infused into the nucleus basalis increases both acetylcholine release in the frontal cortex or amygdala and spatial memory. Neuroscience 87(3) 551-558. [Pg.251]

Another receptor system with which neurosteroids interact is the N-methyl-D-aspartate [NMDA] receptor. Pregnenolone sulfate acts as a positive allosteric modulator of the NMDA receptor, in analogy to GABA-ergic effects, by increasing the frequency and duration of NMDA-activated channel opening [Bowlby 1993 Irwin et al. 1992 Wu et al. 1991]. [Pg.443]

Bowlby MR Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons. Mol Pharmacol 43 813-819, 1993... [Pg.602]

Invernizzi R, Pozzi L, Vallebuona F, et al Effect of amineptine on regional extracellular concentrations of dopamine and noradrenaline in the rat brain. J Pharmacol Exp Ther 262 769-774, 1992b Irwin RP, Magarakis NJ, Rogawski MA, et al Pregnenolone sulfate augments NMDA receptor mediated increases in intracellular Ca in cultured rat hippocampal neurons. Neurosci Lett 141 30-34, 1992... [Pg.664]

Majewska MD, Schwartz RD Pregnenolone-sulfate an endogenous antagonist of the y-aminobutyric acid receptor complex in brain Brain Res 404 355-360, 1987 Majewska MD, Harrison NL, Schwartz RD, et al Steroid hormone metabolites are barbiturate-hke modulators of the GABAa receptor. Science 232 1004-1007, 1986... [Pg.688]

Mathews A, MacLeod C Discrimination of threat cues without awareness in anxiety states. J Abnorm Psychol 95 131-138, 1986 Mathis M, Paul SM, Crawley JN The neurosteroid pregnenolone sulfate blocks NMDA antagonist-induced deficits in a passive avoidance memory task. Psychopharmacology 116 201-206, 1994... [Pg.692]

Melchior CL, Ritzmann RF Dehydroepiandrosterone is an anxiolytic in mice on the plus maze. Pharmacol Biochem Behav 47 437-441, 1994a Melchior CL, Ritzmann RF Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze. Pharmacol Biochem Behav 48 893-897, 1994b Melia PI Prophylactic lithium a double-blind trial in recurrent affective disorders. Br J Psychiatry 116 621-624, 1970... [Pg.695]

Wu FS, Gibbs TT, Farb DH Pregnenolone sulfate a possible allosteric modulator at the N-methyl-D-aspartate receptor. Mol Pharmacol 40 333-336, 1991... [Pg.771]

Pregnenolone sulfate] Synthetic narcotic, protectant against gastric duodenal ulcer] ct-R agonist... [Pg.227]

Liu et al. (2003) focused their method paper on the instrumental set-up for on-line capillary LC coupled with MS-MS via a low flow-rate interface, hoping that miniaturization would improve sensitivity for many biomedical applications. The system design and perfonnance were tested on DHEA sulfate and pregnenolone sulfate quantitation from 5 pL of plasma from one male volunteer. Sample preparation was simple - addition of aqueous methanol and of the deuterated analog internal standards, protein precipitation, supernatant filtration through a Cig bed, evaporation and reconstitution in 100 pL of mobile phase, of which 20 pL were injected for LC-MS-MS analysis. The DHEA sulfate concentration found was in agreement with literature values based on GC-MS and LC-MS studies. [Pg.25]

Steroid sulfate sulfohydrolase Dehydroepiandro-sterone. sulfate, pregnenolone sulfate, estrone sulfate 6.5 0.06 150.0... [Pg.171]

Finally. CS may serve as a precursor of pregnenolone sulfate in human fetal adrenal mitochondria. It is converted to pregnenolone sulfate at a rate of 1.7 nmoles/min/mg protein [137],... [Pg.114]

Itzhak Y, Norenberg MD. 1994. Attenuation of ammonia toxicity in mice by PK 11195 and pregnenolone sulfate. Neurosci Lett 182(2) 251-254. [Pg.197]

Pregnenolone sulfate CABAa GABAergic receptor subtype... [Pg.76]

Examples are also known where a non-physiological enantiomer exhibits higher efficacy than its physiological counterpart. Pregnenolone sulfate is a memory enhancing neurosteroid, but the synthetic (—)-enantiomer is more potent, actions apparently exerted actions different mechanisms since the effects of the physiological enantiomer are... [Pg.462]

Akwa, Y., Ladurelle, N., Covey, D.F. and Baulieu, E.-E. (2001) The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart. Distinct mechanisms. Proc. Natl Acad. Sci. USA 98 14033-14037. [Pg.473]

Malejev A, Gibbs TT, Farb DH. Inhibition of the NMDA response by pregnenolone sulfate revels subtype selective modulation of NMDA receptors by sulfated steroids. Br J Pharmacol 2002 135 901-909. [Pg.651]

See other pages where Pregnenolone sulfate is mentioned: [Pg.47]    [Pg.851]    [Pg.853]    [Pg.966]    [Pg.178]    [Pg.178]    [Pg.179]    [Pg.187]    [Pg.187]    [Pg.441]    [Pg.442]    [Pg.443]    [Pg.444]    [Pg.444]    [Pg.447]    [Pg.347]    [Pg.429]    [Pg.2318]    [Pg.2318]    [Pg.2184]    [Pg.161]    [Pg.204]    [Pg.211]    [Pg.393]    [Pg.634]    [Pg.342]    [Pg.32]    [Pg.205]   
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See also in sourсe #XX -- [ Pg.342 ]

See also in sourсe #XX -- [ Pg.301 , Pg.302 ]

See also in sourсe #XX -- [ Pg.159 , Pg.173 , Pg.194 ]



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