2-amino-4-methoxy

Amino-5-methoxy pyrimidine is obtained having a melting point of about 300°C by condensation of methoxymalonic acid ester with guanidine carbonate in the presence of sodium ethylate. The resultant reaction product is then converted to 2-amino-5-methoxy-4,6-di-chloropyrimidine (melting point 216°C to 217°C) by heating this reaction product with phosphorus oxychloride. The dichloro compound is then suspended in water with zinc dust and... 

Trifluoroacetic acid, 85 ml, was added to 30.5 g (0.0958 mole) of the 5-methoxy-2-(tert-butoxycarbonylamino)-2,3-dihydro-lH-phenalene. The resulting solution was stirred for 20 min. Ice was then added, and the resulting mixture was made pH basic with 20% w/w sodium hydroxide in water solution and stirred for 1 h at room temperature. The mixture was extracted well with chloroform, the chloroform extract was separated and washed with water, with saturated sodium chloride solution dried with magnesium sulfate, and evaporated to give 18.8 g (92% yield) of the 2-amino-5-methoxy-2,3-dihydro-lH-phenalene as a brown oil. 

This 2-amino-5-methoxy-2,3-dihydro-lH-phenalene was converted to its hydrochloride salt in methanol with 1.5 N hydrogen chloride in diethyl ether solution to give 18.11 g of the 2-amino-5-methoxy-2,3-dihydro-lH-phenalene hydrochloride as colorless needle crystals, melting point 252°C (dec.). 

A mixture of 2-amino-5-methoxy-2,3-dihydro-lH-phenalene, 2.6 g (0.0122 mole), released from its hydrochloride, 6.46 g (0.0525 mole) of n-propyl... 

Acetyl-3-amino-5-methyl- E6a, 297 (C1CH2-CHR-CHC1-CN + HS - CH2 - CO - CH3) Thiophenol 2-Amino-5-methoxy- IX, 41... 

N-Ethoxy- E16a, 219 (O-Alkylier.) 2-(2-Hydroxy-ethyl)- XI/2, 314 Propinsaure 2-Amino-5-methoxy-E9a, 695 (N02 - NH2) Quinolin-l-oxid 2,4-Dihydroxy-3-methyl- E7a, 504 [2-NOz—Ar— CO-CH(CH3)-CHO + Boranat Pd —C]... 

Inder Reaktion von Isothiocyanat-allen mit Lithiumazid in Methanol erfolgt einezusatzliche Modifizierung der entstehenden 5-Methyl-Gruppe, so daO 2-Amino-5-(methoxy-methyl)-1,3-thiazol (76% Schmp. 96-97°) gebildet wird1 90. 

Amino-5-methoxycarbonyl-2-[4-(2-mcthoxy-phcnyl)-pipcrazinoj- 152 2-Amino-4-(methoxycarbonyl-methyl)-aus ThiobarnstolT/4-Cbloi -3-oxo-butansaure-mcthylcstcr 48 4-Amino-5-methoxycarbonyl-2-(l-oxo-thiolan-l-ylidenamino)- 152 2-Amino-4-mcthoxycarbonyl-5-phenyl- 64 2-Amino-4-(3-methoxycarbonyl-propyl)- 206 4-Amino-5-mcthoxycarbonyl-2-(2-thicnyl)- 152 2-Amino-5-(methoxy-methyl)- 129 2-Amino-4-(4-methoxy-phenyl)- 90, 223 2-Amino-4-[2-(4-methoxy-phenyl)-ethenyl]- 94 2-Ainino-5-(4-methoxy-phenyl)-4-methyl- 108... 

Amino-7-mercapto-2-mcthyl- 892 2-Amino-5-methoxy- 872 2-Amino-6-methoxy- 877, 961 2-Amino-6-methoxy-5-methyl- 1011 2-Amino-4-methyl- 878 2-Amino-5-methyl- 909 2-Amino-6-niethvl- 878... 

Is tested in the presence of caustic alkaline or carbonates to produce the 2-amino-5-methoxy pyrimidine compound, melting point 80 C to 82 C, (benzene). 

An efficient synthesis of iV-ethyl-l-hydroxy-7-methoxymitosane (115) was reported by Verboom and co-workers [39, 40]. This synthesis was based on a variation of the Madelung reaction in which the cyclization to an indole was facilated by an electron-withdrawing cyano group on the benzylic carbon (Scheme 15). The starting material, 2-amino-5-methoxy-4-methylbenzonitrile (110), was treated with 4-chlorobutyryl chloride to give amide 111, which was... 

Methoxybenzoxazolin-2(3H)-one 752 (MBOA 6-methoxy-2-oxo-2,3-dihydro-benzoxazole) has been found in extracts of plant tissues from gramineous plants such as Coix lachrytna-jobi, wheat, and maize, and is implicated as a chemical resistance factor against fungi and insects. Because MBOA is only available in rather small amounts by plant extraction, several methods have been developed for its chemical synthesis. The most representative synthetic route involves the insertion of a C=0 unit between the amino and hydroxy groups of 2-amino-5-methoxy-phenol 751, a very easily oxidizable substance. 

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