2-Amino-4-methoxy-6-methylpyrimidine

The spectroscopy and dynamics of the excited state double proton transfer in 2-amino-4,6-dimethylpyrimidine and 2-amino-4-methoxy-6-methylpyrimidine has been studied by steady-state and time-resolved fluorescence spectroscopy (01CP(265)233). 

Turning to the 7c-deficient nuclei, we see that 2-amino-3-aminomethyl-pyrazine (see 9) and formaldehyde, in boiling 5 N sodium hydroxide, gave a moderate yield of 1,2,3,4-tetrahydropteridine (see 10) in 5 min.59 4-Amino-5-aminomethyl-2-methylpyrimidine (see 2), when condensed with 4-methoxy-and 4-nitrobenzaldehydes in boiling benzene (a Dean-Stark trap was used), furnished excellent yields of 7-aryl-2-methyl-5,6,7,8-tetrahydropyrimidino-[4,5-d]pyrimidine (see 7). However p-chlorobenzaldehyde did not carry the... 

This antihypertensive (152) [186] was synthesized from 3-amino-4-chloro-2-methoxy-6-methylpyrimidine and 1-acetylimidazolidinone followed by hydrolysis as for indanazoline (118) and tramazoline (122) [187, 188], It is a highly seleetive full agonist to central a2-adrenergic receptors [189] which is reliable and safe in long term treatment of hypertension [190]. In a comparative trial, it proved as effective as clonidine against mild to moderate essential hypertension [191]. 

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