1-Amino-2,2-difluor

Neben den beschriebenen Halogen-, Alkyl-, Alkoxy- und Nitro-Gruppen-substituierten Azobenzolen sind durch Kondensation von Fluor- und Cyan-substituierten Anilinen mit Nitroso-benzolen in saurer Losung auch 4-Butyl-4 -cyan-1, 4-Amino-3,5-difluor-2 und 4-Amino-2,3,5,6-tetrafluor-azobenzol3 zuganglich. 

Alkoxy-methyl-trifluor- E2, 858 Alkoxy-phenyl-trifluor- E2, 858 Alkoxy-tetraphenyl- E2, 887 Alkyl-tctrachlor- E2, 857 Alkyltriazenyliden-triamino- E2, 826 Allylamino-difluor-difluormethyl-hydro- E2, 836 Allyl-tetrachlor- XII/1, 343 Amino-bis-[2,2 -biphenyldiylJ- E2, 883 Amino-difluor-hydro-organo- E2, 836 Amino-organo-trifluor- E2, 859, 860 Aryl-(l-hydroxy-alkyl)-trifluor- E2, 864 Aryl-tetrachlor- E2, 857 Aryltriazenyliden-triamino- E2, 826 Benzyl-bis-[2,2 -biphenyldiyl]-... 

Athylendioxy-3-oxo- 305. 3/3-Amino-17/S-propanoyloxy- 614 16,16-Difluor-17/J-hydroxy-3-oxo- 751 ll,17/3-Dihydroxy-3-oxo- 757... 

A Rh-catalyzed Reformatsky reaction of chiral imine (24) led to the stereoselective preparation of the a,a-difluoro-jS-amino acid (25). 25 was converted to difluor-oalkene (26), and subsequently L-Val-i/r[(Z)CF=CH]Gly derivative (23) in greater than 82% for both steps. The samarium diiodide-mediated reductive transformation of the y,y-difluoro-a, S-enoates proceeded via successive two-electron transfers to form a dienolate species which upon kinetically controlled trapping with fert-BuOH formed 23 (Scheme 6). 

Aus 2,4(5)-Difluor-5(4)-ethoxycarbonyl-imidazol erhalt man durch selektive Substitution des Fluor-Atoms in 2-StelIung mit Ammoniak in Methanol 2-Amino-5(4)-ethoxycarbonyl-4(5)-fluor-imidazol in 65% Ausbeute928. 

Die Ringoffnung von Azirinen mit Fluorwasserstoff/ Pyridin verlauft je nach Substitution und Bedingungen unterschiedlich2,5> 6 unter Bildung von Pyrazinen, a-Fluor-ketonen und/oder 2,2-Difluor-alkylaminen. So erhalt man z.B. aus 2-Methyl-3-phenyl-2H-azirin 2-Amino-1,1-difluor-l-phenyl-propan als Hauptprodukt5. 

P.E. Toren, JOC 32(12), 4045-48(1967) Sc CA 68, 39052 (1968) (Organic fluoronitrogens. DC. Oxidation-reduction reactions of tris (difluor-amino)fluoromethane, tetrafluoroformamidine, and pentafluoroguanidine) 10) C. E. Merrill,... 

Amino group of 2-amino-5-(2,4-difluorophenyl)-6H-pyrido[l,2-fc]pyrida-zin-6-one was reacted with (2-fluorophenyl)isocyanate, with 2,4-difluor-obenzoyl chloride to give 2-[N2-(2-fluorophenyl)ureido] and (2,4-difluor-obenzoyDamino derivatives, respectively (07USA2007/0129372). 

Phosphor(III)-fluorid und -chlorid-difluorid addieren bei 20° Bis-[trifluormethyl]-chlor-amin zu (Bis- tri-fluormethyl]-amino)-chlor-trifluor- bzw. (Bis-[trifluormethyl]-amino)-dichlor-difluor-phosphoran ... 

Diethyl-(4-methoxy-methyl-anilino)- E2, 296 Diethyl-(N-methyl-anilino)- E2, 295, 296 Diethyl-phenoxy- El, 2SI Diethyl-phenyl- -phenylimid XU/1, 177 Difluor-difluormethyl- E2, 836, 854 Difluor-(fluorsulfonyl-methyl)- E2, 857 Difluor-methyl- E2, 836, 854 Difluor-phenyl- E2, 854 Difhior-trifluormethyl- E2, 905 Difluor-triphenyl- E2, 881 Diisopropyloxy-hexyl- El, 135 Diisopropyloxy-methyl- E2, 200, 480 Diisopropyloxy-phenyl- E2. 134, 135, 207 Diisopropyloxy-propyl- E2, 200 Dimcthoxy-methyl- E2, 480 Dimethoxy-phenyl- E2, 204ff, 207, 393, 856, 864 Dimethylamino-diphenyl- E2, 18, 227 Dimethylamino-ethinyl- E2, 230 Dimethylamino-fluor-trifluormethyl- E2, 435 (4-Dimethylamino-phenyl)-diphcnyl- E2, 108 (4-Dimcthylamino-phenyl)-diphcnyl- -(2-nitro-phenylthioimid) E2, 108 Dimethylamino-l-propinyl- E2, 230 (l,l-Dimethyl-butyloxy)-ethyl-methyl- E2, 20, Dimethyl-(diphenylmethylen-amino)- E2, 106 Dimethyl-fluor- E2, 161 Dimethyl-phenyl- E2, 99, 103 Dimethyl-phenyl- -(2-aminocarbonyl-hydrazinocar-bonylimid) E2, 113... 

Grohe, K., et al., 7-Amino-l-cyclopropyl-6,8-difluor-l,4-dihydro-4-oxo-3-chinolin-carbonsauren, Verfahren zu ihrer Herstellung sowie diese enthaltende antibakterielle Millei. 1983, Bayer AG ... 

Propan 3-Chlor-l,2,2-tris-[difluor-amino]- E16a, 902 (HNF2 +Cl-C-C = C-OR)... 

Oxadiazol 3-(Difluor-difluor-amino-methyl)-5-trifluormethyl-E8c. 474 [F2N - CF2 - C(NH2) = N-O-CO-CF3/P4O10]... 

Propan l,3-Difluor-2-hydroxy-2-propanoyl-amino-tetrachlor-E14a/2, 63 (Keton/ R-CO-NH2)... 

Oxazol 4-Amino-2-(chlor-difluor-methyl)-2,5,5-tris-[tri-fluor-methyl]-2,5-dihydro-E14a/2, 685... 

H-l,3,5-Oxadiazin 4,4-Bis-[chlor-difluor-methyl]-2,6-bis-[diethyl-amino]- E4, 1102 (R2N —CN + Keton)... 

Difluor-bis-[difluormethylen-amino]- 1130 Difluor-dichlor- 1143 Diisoprophyloxy-phenyl- 1080 Dijod- 629... 

Amino-1,l-difluor-alkane286kovalente Strukturen, wahrendin alien anderen Fallen Dis-soziation erfolgt. 

The chemistry of (difluoramino)dinitroacetonitrile was further explored as well [84,85] it underwent common transformations such as hydrolysis to (difluoramino)dinitroacetamide reaction with HCl in anhydrous methanol to form the 0-methyl imidate hydrochloride trimerization to 2,4,6-tris[(difluor-amino)dinitromethyl]-l,3,5-triazine and reaction with azides (NaNs, HN3) to make 5-[(difluoramino)dinitromethyl]tetrazoles. 

Nazin and coworkers measured thermal decomposition of a-(difluor-amino)polynitroalkanes and concluded that (difluoramino)dinitroalkanes differ little in their stability from their nitro analogs, trinitroalkanes [94,95]. Bis[2-(difluoramino)-2,2-dinitroethyl]nitramine (13) was not one of the examples in this study, however. 

A fundamentally new preparation of internal and terminal gem-bis(difluor-amino)alkanes was demonstrated by Chapman et al. [140] via the direct fluorination of the corresponding gem-bisacetamides, with 1,1-bisacetamidocyclo-hexane and 1,1-bisacetamidopropane used as examples, leading to 1,1-bis(difluoramino)cyclohexane and l,l-bis(difluoramino)propane, respectively (Scheme 18). l,l-Bis(difluoramino)cyclohexane behaved less than ideally as a model system its yield by conventional difluoramination is atypically... 

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