Amines ethyl formate

Piridicillin (27) is made by ]T-acylating amoxycillin with a rather complex acid. The synthesis begins by reacting j, ]i-diethanol amine with. c ty i zene-sul fonyl chloride to give 23. Conversion (to 24) with ethyl formate and sodium... 

ETHYLENE GLYCOL ETHYL MERCAPTAN DIMETHYL SULPHIDE ETHYL AMINE DIMETHYL AMIDE MONOETHANOLAMINE ETHYLENEDIAMINE ACRYLONITRILE PROPADIENE METHYL ACETYLENE ACROLEIN ACRYLIC ACID VINYL FORMATE ALLYL CHLORIDE 1 2 3-TRICHLOROPROPANE PROPIONITRILE CYCLOPROPANE PROPYLENE 1 2-DICHLOROPROPANE ACETONE ALLYL ALCOHOL PROPIONALDEHYDE PROPYLENE OXIDE VINYL METHYL ETHER PROPIONIC ACID ETHYL FORMATE METHYL ACETATE PROPYL CHLORIDE ISOPROPYL CHLORIDE PROPANE... 

Serine has been prepared by the Strecker method from glycol-aldehyde 1 and from ethoxyacetaldehyde,2 3 by the condensation of ethyl formate with ethyl hippurate followed by reduction and hydrolysis,4 5 from the reaction product of chloromethyl ether with ethyl sodium phthalimidomalonate,6 and by amination of a-bromo-/3-methoxypropionic acid with subsequent demethyla-tion.7... 

C02 reacts with ethanol and H2 in presence of a tertiary amine to give ethyl formate (equation 150).583 The cobalt complexes [CoH(diphos)2] (123) and [Co(HC02)(PPh3)3] (124) gave only low turnover numbers, with complex (123) being the better catalyst of the two. [RhCl(PPh3)3] (23) and [Ir(H)3(PPh3)3] (38) were more efficient. The presence of the base was essential but its function is unknown. 

Isoprene [78-79-5] (2-methyl-1,3-butadiene) is a colorless, volatile liquid that is soluble in most hydrocarbons but is practically insoluble in water. Isoprene forms binary azeotropes with water, methanol, methyl amine, acetonitrile, methyl formate, bromoethane, ethyl alcohol, methyl sulfide, acetone, propylene oxide, ethyl formate, isopropyl nitrate, methylal (dimethoxymethane), ethyl ether, and -pentane. Ternary azeotropes form with water—acetone, water—acetonitrile, and methyl formate—ethyl bromide (8). Typical properties of isoprene are listed in Table 1. 

N,N-Dialkylformamide or ethyl formate" and Grignard reagents have been used with some success however, the former reaction is complicated and frequently produces tertiary amines as the chief product, and the latte forms secondary alcohols by further reaction of the aldehyde. Substituted benzaldehydes have been prepared from aryllithium compounds and N-methylformanilide in good yields. ... 

Racemic 2-aminobutan-l-ol (1) is a cheap chemical which can be easily resolved into both its enantiomers on an industrial scale. The asymmetric synthesis of chiral amines from hydrazines derived from (7 )-(—)-2-aminobutan-l-ol [(R)-(—)-l], using the general strategy disclosed in early works, is summarized here. The title hydrazine (4) is prepared as follows (eq 1). Treatment of the amino alcohol [(7 )-(—)-l] with excess ethyl formate followed by LAH reduction of the intermediate formamide gives the N-methylamine [(7 )-(—)-2]. IV-Nitrosation of the latter afforded (R)-(+)-3 which is next reduced to the hydrazine [( )-(—)-4] by means of LAH. Being unstable, the hydrazine (4) must be used immediately without purification. 

Those 3(2//)-furanones with a methylene group at the 2-position condense with ethyl formate and amines to give aminomethylene derivatives of type 46. In such compounds the heterocyclic ring is easily opened by nucleophiles because the functional grouping is that of a vinylogous ester with amines,... 

N-Cyclohexylformamide, prepared by slowly adding ethyl formate to cyclo-hexylamine with stirring and cooling, is an intermediate in an efficient method for conversion of the amine to cyclohexyl isocyanide. ... 

Primary and some secondary amines can be formylated in good yield by heating the amine with ethyl formate at 100-110° for I hr. in an autoclave." Under the same conditions ethyl acetate does not react. 

Formylation of amines with ethyl formate is of general preparative value. Largo quantities can be formylated quickly in a steel pressure vessel.—E / -Naphthylamine heated 1 hr. with 10 moles of ethyl formate at 100-110° —> formyl-jd-naphthylamine. Y nearly 100%. (I. P. E. Human and J. A. Mills, Soc. 1948, 1457.)... 

Mita and coworkers have developed an assay for histamine, in which the amine is extracted from basified aqueous solution, derivatized with HFBA, and then with ethyl formate. The detection limit on GC-FID is claimed to be 20 ng. This technique can be applied to the analysis of HA and... 

Reduction of an amide provides a route to amine derivatives since the oxygen atom is removed. Forma-mide derivatives are easily synthesized by reaction of amines with ethyl formate, for example, and subsequent reduction provides an effective method for monomethylation and dimethylation of amines. Reaction of 2-phenylethanamine with formaldehyde and formic acid gave iminium salt 33 as a reactive intermediate, which... 

This conclusion was supported by the observation that pyrolysis of 3-butenol has a AS of —8.8 eu, which is similar to the activation entropy values reported for pyrolysis of ethyl formate and for 3-butenoic acid, and the activation energies for all three pyrolyses are also similar (about 40 kcal/mol). Another well-known concerted syn elimination is the Cope elimination, which involves the thermal elimination of an alkene from an amine oxide (Figure 10.53). Unlike the reactions discussed above, all of which have... 

Optically active (+)-methyl-2-thienylmethanol has been obtained through reduction of 2-acetylthiophen with a lithium aluminium hydride-quinine complex. The 2-thienyl analogues of ephedrine and 0-ephedrine have been synthesized from 2-propionylthiophen via the a-bromo-derivative and the methylamino-ketone, followed by borohydride reduction. The amines were resolved into optical antipodes. Through the Claisen condensation between 2-acetylthiophen and ethyl formate, followed by the reaction with secondary amines, compounds of type (164) were obtained. 

---