Amine tests

Z>) Benzoylation. Proceed exactly as for benzoylation of amines (Test 3 (a), p.374), but use a suspension of the finely ground nitroaniline in the 10% NaOH solution. This preparation of the benzoyl derivatives is rarely necessary, however, as the above acetylation proceeds very satisfactorily. (M.ps., p. 550.)... 

The isomerization of 5-vinyl-2-norbornene to 5-ethylidene-2-norbornene has been performed using a catalytic system consisting of an alkali metal hydride and an amine. The activity of the alkali metal hydride increased with increasing size of the alkali metal KH > NaH > LiH. Among the various amines tested, only aliphatic 1,2-diamines exhibited the activity for the isomerization. Electron paramagnetic resonance (EPR) and UV-visible spectroscopic experiments on the active species suggest that the isomerization of 5-vinyl-2-norbornene proceeds through a radical mechanism.167... 

Wasicky, R. and Frehden, O., Spot-plate tests in the examination of drugs. I. Aldehyde and amine tests for the recognition of ethereal oils, Mikrochim. Acta, 1, 55, 1937 Chem. Abs., 31, 5944, 1937. 

Further Observations on the Diphenyl amine Test for Gunpowder Residue" FBI Law Enforcement Bulletin (191 0) 2., 10... 

Besides the above mentioned cinchona based system, to date only a few nitrogen-based chiral ligands have been reported to work under catalytic conditions70-72. The C2-symmetrical l,4-diazabicyclo[2.2.2]octane (DABCO) derivative l70 and the isoxazolidines 2 and 371 are examples. The main problem with most of the other amines tested stems from the formation of ligand-osmate ester complexes which are too stable. Although with these ligands the levels of enantiomeric excess are still not satisfactory, the successful osmium turnover gives hope for future improvements. 

However, he did find an absorption band at 6.05 n for solid A -o-tolyl-o-glucosylamine, and also for fV-2-naphthyl-D-glucosylamine, indicating for the first time the existence of a Schiff-base structure for A -substituted glucosylamines in the solid state. For the other A -substituted o-glucosyl-amines tested (A-phenyl, A-p-nitrophenyl, and A-m-nitro-p-tolyl), no Schiff-base structure was indicated. All compounds exhibited a band at 2.88 n which could have been given by either an NH or an OH grouping. 

If the substance is readily soluble in cold water and if the odor is suggestive of an amine, test the solution with pH paper and further determine if the odor disappears on addition of a few drops of 10% hydrochloric acid. If the properties are more like those of a salt, add a few drops of 10% sodium hydroxide solution. If the solution remains clear, addition of a little sodium chloride may cause separation of a liquid or solid amine. 

The various amines tested were compared for their influence on the retention behaviour of the... 

Allyl sulfides and allyl amines. Rhodium-catalyzed decomposition of ethyl diazoacetate in the presence of these allyl compounds generates products 136 and 137, respectively, derived from [2,3] rearrangement of an S- or N-ylide intermediate, besides small amounts of carbene dimers No cyclopropane and no product resulting from the ylide by [1,2] rearrangement were detected. Besides RhjfOAc) and Rhg(CO)i6, the rhodium(I) catalysts [(cod)RhCl]2 and [(CO)2RhCl]2 were found to behave similarly, but yields with the only allyl amine tested, CH =CH—CH NMe, were distinctly lower with the latter two catalysts. Reaction temperatures are higher than usually needed in rhodium-promoted diazoalkane decomposition, which is certainly due to competition between the diazo compound and the allylic hetero-... 

From structure CXCIX, it might be expected that haemanthidine exists in equilibrium with the open chain and hemiacetal forms (CCII, R = H and CCIII, R = H, respectively). It would appear that only a very small amount of CCII (R = H) can be present at any one time, since the alkaloid shows no carbonyl band in the infrared and a normal methylenedioxyphenyl ultraviolet spectrum. Haemanthidine, spotted on paper, gives no secondary amine test with alkaline sodium nitro-prusside and acetaldehyde. However, it seems likely that, under certain... 

The stage was then set for Ahlquist s (1948) classic experiments leading to the proposal of a and 3 adrenoceptors. The research was based on sensitivities to NE and EP and related substances. In essence, he discovered an inverse potency relationship between producing excitation in smooth muscles (peripheral vasoconstriction, uterus, ureter) and intestinal smooth muscle inhibition—Set A—and the production of vascular inhibition (vasodilation) and of the uterus, and cardiac excitation—Set B. The experimentation utilized dogs, cats, and rabbits as well as isolated animal tissues. The amines tested showed a decreasing potency in the order listed for Set A effects, and the opposite for Set B effects ... 

As in the case of the carcinogens whose activity can be substantially reduced by anticarcinogens [see review by Rodgman (3255)], Lee et al. (2327c) reported that mainstream CSC significantly inhibited the mutagenicity of several of these A-heterocyclic amines when tested in the Ames assay with Salmonella typhimurium, strain TA 98 in the presence of the S-9 mix. The A-heterocyclic amines tested included 2-amino-3-methylimidazo[4,5-/]quinoline (IQ), 2-amino-3,4-dimethylimidazo[4,5-/]quinoline (MelQ), 2-amino-6-methyl-dipyrido[l,2-fl 3 ,2 - /]imidazole(Glu-P-l), 2-aminodipyrido[l,2-fl 3 ,2 - /]imidazole (Glu-P-2), 3-amino-... 

Lee et al. (2327c) reported that the CSC from cigarette MSS significantly inhibited the mutagenicity of several A-heterocyclic amines as measured in the Ames assay with Salmonella typhimuriwn, strain TA 98 in presence of the S-9 mix. The A-heterocychc amines tested included ... 

The quaternary amine is lon-palred at pH 10.2 and extracted into chloroform. Primary, secondary, and tertiary amines tested through the procedure did not complex or Interfere with the subsequent spectrophoto-metrlc determination at 5 0 nm. 

Isolated CFl shows a Ca-dependent activity of ATP hydrolysis in the presence of 20 % ethanol (7). Under these conditions, the amines tested had no significant inhibitory effect on ATP hydrolysis (data not shown). The coupling factor apparently is no target for t-amine ef-... 

If the amine test is positive, repeat steps 1-4. If the test is negative, collect the modified peptide-resin, wash with DCM (15 ml), MeOH (10 ml), and dry in vacuo. 

In addition to EDA, some other amines were tested as the carrier of CO2. Typical results are shown in Table IV. As the chain length of the diamine increases, both the permeation rate and the selectivity decreases. With re ct to amines having additional amine groups, such as diethylenetriamine and triethylenepentamine, a increase in molecular weight of the carrier also decreases both Rc02 wd a This may be due to lower diffusivity of larger molecules in the membrane. Thus, among the amines tested, ethylenediamine was found to be the best carrier of CO2. 

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