Biogenic amine receptors

Ishiguro, M. (2004) Ligand-binding modes in cationic biogenic amine receptors. Chembiochem A European Journal of Chemical Biology, 5, 1210. 

Figure 7. A schematic diagram of the proposed ligand binding domains, shown in light grey, in various GPCRs. The helices are shown as cylinders, the loops, N-termini and C-termini are shown as lines. (A) Biogenic amine receptors, (B) Peptide receptors, (C) Glycoprotein hormone receptors, (D) Thrombin receptor.

A third a2-suhiype was cloned first from a rat kidney cDNA library screened with an oligonucleotide complementary to a highly conserved region found in all biogenic amine receptors that had been described up to that time (57). It was called the a2-RNG (for rat nonglycosylated) and was correctly identified as the... 

The biological activities of the different appetite suppressants are summarized in Table 15.9. Because these drugs can increase synaptic levels of multiple neurotransmitters, they often exhibit complex polypharmacology by interacting with entire families of biogenic amine receptors that often have multiple functions. 

Benton R, Vannice KS, Vosshall LB (2007) An essential role for a CD36-related receptor in pheromone detection in Drosophila. Nature 450 289-293 Blenau W, Baumann A (2001) Molecular and pharmacological properties of insect biogenic amine receptors lessons from Drosophila melanogaster and Apis mellifera. Arch Insect Biochem Physiol 48 13-38... 

I-MIP-lot displacement). Compound (11) appears to be selective for CCRl, in that it has no effect on the chemokine receptors CCR2, I OCRS, and CXCR4, or a select panel of biogenic amine receptors (87). There are no in vivo data reported for (11), perhaps because of the variable species similarity between human and mouse sequences. The homology between mouse/human CCRl is 79%. In an effort to compare response of a CCRl antagonist... 

Many naturally occurring and synthetic drugs directed at biogenic amine receptors contain a basic tertiary amine center. It is common practice in the development of new central nervous system (CNS)-active pharma-ceuticals to incorporate pyrrolidino, piperidino, or morpholino moieties (in addition to dimethylamino) in structure-activity investigations. A significant number of cyclic tertiary amine drugs have thus appeared (and continue to appear) in the marketplace despite the fact that this structural construct appears to be especially... 

Biogenic amine receptors (adrenergic, serotonin, dopamine, muscarinic, histamine)... 

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