Alzet® osmotic pump

ALZET Osmotic Pumps (Durect Corp., Cupertino, CA) Silastic tubing (Dow-Corning Corp., Midland, MI)... 

ALZET Osmotic Pumps are miniature, infusion pumps for the continuous dosing of drugs to mice. These minipumps can be surgically implanted intraperitoneally or subcutaneously to transport... 

Figure 4.17 Cross-sectional view of the Alzet osmotic pump, showing the various structural components...

Fig. 19 (A) Cross-sectional view of the Alzet osmotic pump, an osmotic pressure-activated drug-delivery system. (B) The effect of 7 days of subcutaneous delivery of antidiuretic hormone (vasopressin) on the daily volume of urinary excretion and urine osmolality in the Brattleboro rats with diabetes insipidus.

Alzet osmotic pumps were from Durect Corporation, Cupertino, CA. 

Bittner B, Thelly T, Isel H, et al. The impact of co-solvents and the composition of experimental formulations on the pump rate of the ALZET osmotic pump. Int J Pharm 2(X)0 205 195-198. 

Drug solutions and implantation of osmotic mini-pumps Physostigmine hemisulphate and procyclidine hydrochlorid were obtained from Sigma (St.Louis, U.S.A.), scopolamine hydrobromid from Merck (Darmstadt, Germany), atropine sulphate was obtained from ACF (Amsterdam, The Netherlands), and diazepam from Roche (The Netherlands). HI-6 was made available by the Defence Research Establishment, Suffield, Canada. Soman (O-pinacolyl methylphosphonofluoridate) was synthesised at TNO. Alzet Osmotic Mini-pumps with a constant delivery rate of 0.55 pl/hr (Model 2002, Alza Corp., Palo Alto, USA) were used to deliver PYR, PHY and SCO. The vehicle consisted of 20% propylene glycol, 10% ethanol and 70% water. The pumps were implanted subcutaneously under isoflurane/02 inhalation anesthesia. 

In parenteral therapy, the subcutaneously implantable, osmotic mini-pumps developed by the Alza Corp. are used widely in experimental animal studies. The DUROS implant pump is a modified version of the Alzet pumps and was developed specifically for the controlled delivery of peptides and proteins (see Section 4.6.1.2). Osmotic mini-pumps, such as the Oros osmotic pump, are also available for controlled... 

The Duros implant pump is a modified version of the Alzet miniosmotic pump which additionally contains a piston to control drug flow, between the osmotic engine and the drag resorvoir (Figure 4.18). 

Model 2001 ALZET Osmotic Minipump Theoretical Pumping Rate 1.0 yl/hr Actual Pumping Rate 1.03 + 0.04 pl/hr... 

Pa-kins L, Peer C, Fleming V. Pumps/osmotic— alzet system. In Mathiowitz E, ed. Encyclopedia of Controlled Drag Delivery, Vol 2. New York John Wiley, 1999. 

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