Alopecia, scarring

Dermal corrosion is the production of irreversible damage of the skin namely, visible necrosis through the epidermis and into the dermis, following the application of a test substance for up to four hours. Corrosive reactions are typified by ulcers, bleeding, bloody scabs, and, by the end of observation at 14 days, by discoloration due to blanching of the skin, complete areas of alopecia, and scars. Histopathology should be considered to evaluate questionable lesions. ... 

Dermatology Topical steroids are useful in keloids, hypertrophic scars, other localised hypertrophic, infiltrated, inflammatory lesions of lichen planus, psoriatic plaques, granuloma annulare and lichen simplex chronicus discoid lupus erythematosus, necrobiosis lipoidica diabeticorum and alopecia areata. 

Diffuse non-scarring alopecia occurred in a 37-year-old premenopausal woman with relapsed breast cancer 6 months after she had started to take letrozole 2.5 mg/ day and triptorelin 3.75 mg every 28 days it resolved with topical minoxidil (20). 

There are three forms of hair invasion ectothrix (M. canis, M. audouinii, Microsporum ferrugineum, Trichophyton verrucosum), endothrix (Trichophyton tonsurans, Trichophyton violaceum, Trichophyton soudanense) and favic (Trichophyton schoenleinii). Favus is a rarely seen condition in small endemic areas of Northern Africa, the Middle East and the USA. It presents with typical dish-like crusts (scutulae) and scarring alopecia and may also affect adults. 

Two patients developed hchenoid skin eruptions, which subsided when the drug was stopped, although one of these was left with severe scarring, alopecia of the scalp, and widespread atrophic and hyperpigmented skin lesions. 

These include alopecia areata, liposuction scars, neurogenic excoriations and rosacea. TCA has often been tried on vitiligo, but without success. 

As for other reactive hair products, the primary safety concerns for permanent waves generally arise from misuse or failure to comply with the product s usage instructions. Skin irritation, hair breakage, oral toxicity, sensitization, and scarring alopecia either have been reported in the hterature or are referred to in the warning instructions for home permanent-wave products. 

Variants with scarring alopecia (and deafness and keratitis)... 

An unusual manifestation of lamellar ichthyosis is scarring alopecia which probably results from recurring infections of the scalp (Figure 13.6). Other cases have been described with both alopecia, congenital deafness and keratitis . The reported patients occurred sporadically with no family history of similar cases. 

Figure 13.6 Woman with lamellar ichthyosis and scarring alopecia Harlequin fetus...

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