Allergic lung disease animal models

There is a clear need to study the effect of brief and prolonged urban air particulate inhalation on healthy and diseased animals to investigate mechanisms of particulate-enhanced infectious and allergic lung disease. These experiments will require better animal models of human disease, as well as improved engineering teclmiques to either harness or create realistic pollution episodes. Finally, in vitro comparisons of human and animal cells will provide a rational basis for extrapolating from animal toxicology data to potential health effects in humans. 

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