Alkyl dextran

Poly(Ethylene Glycol)-Alkyl Dextran Ether (DexPEGi0C )... 

Dicarboxyethyl dextran 2-(Diethylamino)ethyl 2-Hydroxyoctyl- and 2-hydroxydodecyl Poly(ethylene glycol)-alkyl dextran ether 2-Hydroxy-3-phenoxy propyl dextran ethers Dynamic light scattering N,N- Dime thylace tamide 4-N.N-Dimethylaminopyridine Dextran propionate acetate... 

Amphiphilic poly(ethylene glycol)-alkyl dextran ethers are emerging as vehicles in the oral delivery of poorly water soluble drugs [251,268,269]. They form polymer micelles of low critical association concentrations (CAC) and small micelle sizes in aqueous solution. Particulate delivery systems lead to an enhancement of the absorption efficiency and bioavailability of highly hpophihc drugs orally applied, and provide the drug with some level of pro-... 

As in the deoxyribonucleotide series, gel filtration has been used to separate larger blocks after condensation, an example being the separation of the protected nonamer CpGpUpCpCpApCpCpA from a hex-amer and a trimer.112 However, the lower solubility of protected oligo(ribonucleotide) blocks demands the use of an alkylated dextran... 

A homologous series of water-soluble alkyl-dextrans varying in the length of their hydrocarbon side-chain (63) have been synthesized by reaction of the appropriate alkylamine with dextran cyclic imidocarbonate. The derivatives were used in an affinity electrophoretic study of the interaction between phosphorylase and hydrophobic groups. As the length of the hydrocarbon... 

Figure 8 Formation of Gd +-loaded nanoparticles through non-covalent self-assembly of guest inclusion complexes between alkylated dextran, poly-/S-cyclodextrin, and adamantyl-modified Gd-D03A derivatives. The alkyl chains on the dextran are in yellow, and the Gd-D03A derivatives are represented by the pnrple cylinders. (Adapted from Ref. 32. Wiley-VCH, 2008.)...

Another approach uses reactive alkyl halogen compounds containing a terminal carboxylate group on the other end to form spacer arms off the dextran polymer from each available hydroxyl. In this manner, Brunswick et al. (1988) used chloroacetic acid to modify the hydroxyl groups to form the carboxymethyl derivative. The carboxylates then were aminated with ethylene diamine to create an amine-terminal derivative (Inman, 1985). Finally, the amines were modified with iodoacetate to form a sulfhydryl-reactive polymer (Figure 25.14). 

Methylation- or combined methylation-ethylation reactions were used for structure analysis of polysaccharides. The alkylation of dextran can be applied to the investigation of the branching pattern, i.e. the number and length of side chains (Sect. 2.2) [22,23]. The methylation is carried out in liquid ammonia with sodium iodide and methyl iodide, yielding products that are soluble in chloroform and tetrachloroethane [257]. 

In contrast to the hydrophilic DEAE dextran, new hydrophobically modified polycationic dextran (HMPC) was synthesised, carrying pendant N-alkyl-N,N-dimclhyl-N-(2-hydroxypropyl)ammonium chloride groups, with alkyl being an octyl, dodecyl or cetyl moiety (Fig. 46, [193]). 

Poly(alkyl-cyanoacrylate) Nanoparticles The applications of poly(alkyl-cyanoacrylate) nanoparticles have been reviewed elsewhere and therefore only representative examples are described [102], Because of their adhesive properties, nanoparticles have the potential to prophylactically treat candidiasis of the oral cavity [121], Not surprisingly, poly(alkyl-cyanoacrylate) nanoparticles have been used to deliver drugs to tumors [122], Enhanced absorption and prolonged hypoglycemic effect were observed when insulin was delivered in poly(alkyl-cyanoacrylate) nanoparticles [121], Nuclear accumulation of antisense oligonucleotides into vascular smooth muscle cells was increased when delivered using poly(alkyl-cyanoacrylate) nanoparticles [123]. Dextran-coated poly(alkyl-... 

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