Hypotension aldesleukin interleukin

Miscellaneous Aldesleukin (Interleukin 2) C++,G+, H+,M+, N+, P+, R+ Commonly causes capillary leak syndrome resulting in severe hypotension,... 

Interleukin-2 (Aldesleukin, IL-2) Reversible syndrome of hypotension, oliguria, fluid retention, azotemia, and a very low urinary excretion of sodium Capillary leak syndrome Acute interstitial nephritis Steroids and plasma exchange... 

Interleukins are a family of cytokines, substances secreted by T-cells (lymphocytes), monocytes, macrophages, and other cells. Recombinant IL-2, known generically as aldesleukin, is effective in the therapy of a small percent of patients with renal cell carcinoma and melanoma, sometimes with very gratifying results. Its toxicity is dose-, route-, and time-dependent. At its worst, high-dose intravenous prolonged infusions cause fever, fluid retention, hypotension, respiratory distress, capillary-leak syndrome, suppression of hematopoiesis, nephrotoxicity, and hepatotoxicity. 

Interleukin-2 Human recombinant lL-2 aldesleukin, proleukin des-alanyl-1, serine-125 human lL-2) differs from native lL-2 in that it is not glycosylated, has no amino terminal Ala, and has an Ser substituted for the Cys at amino acid 125. The potency of the preparation is represented in International Units in a lymphocyte proliferation assay such that 1.1 mg of recombinant lL-2 protein equals 18 million International Units. Aldesleukin has the following in vitro biologic activities of native lL-2 enhancement of lymphocyte proliferation and growth of lL-2-dependent cell lines enhancement of lymphocyte-mediated cytotoxicity and killer cell activity and induction of interferon-7 activity. In vivo administration of aldesleukin in animals produces multiple immunologic effects in a dose-dependent manner. Cellular immunity is profoundly activated with lymphocytosis, eosinophilia, thrombocytopenia, and release of multiple cytokines e.g., TNF-a, lL-1, interferon-7). Aldesleukin is indicated for the treatment of adults with metastatic renal cell carcinoma and melanoma. Administration of aldesleukin has been associated with serious cardiovascular toxicity resulting from capillary leak syndrome, which involves loss of vascular tone and leak of plasma proteins and fluid into the extravascular space. Hypotension, reduced organ perfusion, and death may occur. An increased risk of disseminated infection due to impaired neutrophil function also has been associated with aldesleukin treatment. 

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