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Albendazole Diethylcarbamazine

Antihistamines may be given for the first few days of therapy to limit allergic reactions, and corticosteroids should be started and doses of diethylcarbamazine lowered or interrupted if severe reactions occur. Cures may require several courses of treatment. For patients with high L loa worm burdens (more than 2500 circulating parasites/mL), strategies to decrease risks of severe toxicity include apheresis, if available, to remove microfilariae before treatment with diethylcarbamazine or therapy with albendazole, which is slower acting and better tolerated, before therapy with diethylcarbamazine or ivermectin. [Pg.1149]

Bockarie MJ etal Efficacy of single-dose diethylcarbamazine compared with diethylcarbamazine combined with albendazole against Wuchereria bancrofti infection in Papua New Guinea. Am J Trap Med Hyg 2007 76 62. [PMID 17255231]... [Pg.1158]

Ramzy RM et al Effect of yearly mass drug administration with diethylcarbamazine and albendazole on bancroftian filariasis in Egypt A comprehensive assessment. Lancet 2006 367 992. [PMID 16564361]... [Pg.1159]

Supali T et al Doxycycline treatment of Brugia malayi-infected persons reduces microfilaremia and adverse reactions after diethylcarbamazine and albendazole treatment. Clin Infect Dis 2008 46 1385. [PMID 18419441]... [Pg.1159]

Shenoy RK, Dalia S, John A et al. (1999) Treatment of the mi-crofilaraemia of asymptomatic brugian filariasis with single doses of ivermectin, diethylcarbamazine or albendazole, in various combinations. Ann Trop Med Parasitol 93 643-651... [Pg.642]

Encephalopathy is an adverse event related to the treatment of L. loa with diethylcarbamazine or ivermectin, and it has also been related to albendazole (11). [Pg.51]

Shenoy RK, Suma TK, John A, Arun SR, Kumaraswami V, Fleckenstein LL, Na-Bangchang K. The pharmacokinetics, safety and tolerabihty of the co-administration of diethylcarbamazine and albendazole. Ann Trop Med Parasitol 2002 96(6) 603-14. [Pg.1117]

As antihehninthic drugs go, ivermectin can be considered a reasonably safe drug, and it is generally better tolerated than diethylcarbamazine. Clinical experience has often shown relatively little toxicity, although mild adverse effects, presumably due to the kilting of the microfilariae, involve at least one-third of patients some work has suggested that neutrophil activation may play a role in the development of these reactions (1). It has also been well tolerated in combinations, for example when given with albendazole in order to kill adult worms (which cannot be achieved with ivermectin alone) or with diethylcarbamazine for bancroftian filariasis (SEDA-20, 281). [Pg.1946]

W. bancrofti, the efficacy of a single dose of albendazole 600 mg alone or in combination with ivermectin 400 pg/kg or diethylcarbamazine 6 mg/kg was compared with a single dose of the combination diethylcarbamazine 6 mg/kg and ivermectin 400 pg/kg over a period of 15 months after treatment. Albendazole plus ivermectin was the most effective regimen for clearing microfilariae. Nine of 13 subjects (69%) were amicrofilaremic 15 months after treatment compared... [Pg.413]

Albendazole is combined with either diethylcarbamazine or ivermectin in programs directed toward controlling LF. By annual dosing with combination therapy for 4-6 years, the goal is to maintain the microfilaremia at such low levels that transmission cannot occur for a period that corresponds to the duration of fecundity of adult worms. Albendazole is given with diethylcarbamazine to control LF in most parts of the world. To avoid serious reactions to dying microfilariae, an albendazole/ivermectin combination is recommended in locations where filaiiasis coexists with either onchocerciasis or loiasis. [Pg.700]

Annual single doses of both diethylcarbamazine and albendazole show considerable promise for the control of lymphatic filariasis in regions where onchocerciasis and loiasis are not endemic. [Pg.701]

For mass treatmerU programs, the introduction of diethylcarbamazine into table salt (0.2-0.4% by weight of the base) has markedly reduced the prevalence, severity, and transmission of lymphatic filariasis in many endemic areas. Diethylcarbamazine given annually as a single oral dose of 6 mg/kg is most effective in reducing microfilaremia when coadministered with either albendazole (400 mg) or ivermectin (0.2-0.4 mg/kg). Adverse reactions to microfilarial destruction usually are well tolerated. However, mass chemotherapy with diethylcarbamazine should not be used in regions where onchocerciasis or loiasis coexist because it may induce severe reactions related to parasite burden in these infections. [Pg.701]

Benzimidazoles M = Mebendazole, A = Albendazole DEC = Diethylcarbamazine IVM - ivermeclin PZQ = Praziquanlei PP -Prantel pamoate. [Pg.1695]

There appears to be no pharmacokinetic interaction between albendazole and diethylcarbamazine. [Pg.210]

Gunawardena S, Ranganathan SS, Fernandopulle R. Pharmacovigilance through consumer feedback (reporting) in the mass treatment of lymphatic filariasis using diethylcarbamazine and albendazole in two districts of Sri Lanka. Trop Med Int Health 2008 13(9) 1153-8. [Pg.651]


See other pages where Albendazole Diethylcarbamazine is mentioned: [Pg.583]    [Pg.558]    [Pg.1115]    [Pg.469]    [Pg.210]    [Pg.583]    [Pg.558]    [Pg.1115]    [Pg.469]    [Pg.210]    [Pg.1148]    [Pg.1151]    [Pg.640]    [Pg.630]    [Pg.1115]    [Pg.1115]    [Pg.1116]    [Pg.1117]    [Pg.1117]    [Pg.1117]    [Pg.163]    [Pg.403]    [Pg.414]    [Pg.420]    [Pg.695]    [Pg.697]    [Pg.698]    [Pg.699]    [Pg.702]    [Pg.703]    [Pg.210]    [Pg.647]    [Pg.459]   
See also in sourсe #XX -- [ Pg.210 ]




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