Agonists chronic treatment

Cory-Slechta DA, McKoy L, Richfield EK. 1997c. Time course and regional basis of Pb-induced changes in MK-801 binding Reversal by chronic treatment with the dopamine agonist apomorphine but not the D1 agonist SKF-82958. J Neurochem 68 2012-2023. 

Human delta opioid receptor Functional studies on stably transfected Chinese hamster ovary cells after acute and chronic treatment with the selective non-peptidic agonist SNC-80. J Pharmacol Exp Ther 1996 278 1083-1089. 

Dennis J. McKenna, Adil J. Nazarali, Akihiko Himeno, and Juan M. Saavedra. "Chronic treatment with (+J)DOI, a psycho-tomimetic 5HT2 agonist, downregulates 5HT2 receptors in rat brain." Neuropsychopharmacology 2 (1989) 81-87. 

Papadimitriou GN, Kerkhofs M, Kempenaers C, et al EEG sleep in patients with generalized anxiety disorder. Psychiatry Res 26 183-190, 1988 Papadimitriou GN, Christodoulou GN, Katsouyanni K, et al Therapy and prevention of affective illness by total sleep deprivation. J Affect Disord 27 107-116, 1993 Papp M, Muscat R, Willner P Additive effects of chronic treatment with antidepressant drugs and intermittent treatment with a dopamine agonist. Eur Neuropsy-chopharmacol 2 121-125, 1992... 

Serra G, Forgioni A, D Aquila PS, et al Possible mechanism of antidepressant effect of L-sulpiride. Chn Neuropharmacol 13 (suppl l 576-583, 1990a Serra G, CoUn M, D Aquila PS, et al Possible role of dopamine D1 receptor in the behavioral supersensitivity to dopamine agonists induced by chronic treatment with antidepressants. Brain Res 527 234-243, 1990b Sershen H, Hashim, A, Lajtha A Behavioral and biochemical effects of nicotine in an MPTP-induced mouse model of Parkinson s disease. Pharmacol Biochem Behav 28 299-303, 1987... 

Treatment with omalizumab, the monoclonal humanized anti-IgE antibody, is reserved for patients with chronic severe asthma inadequately controlled by high-dose inhaled corticosteroid plus long-acting B-agonist combination treatment (eg, fluticasone 500 meg plus salmeterol 50 meg inhaled twice daily). This treatment reduces lymphocytic, eosinophilic bronchial inflammation and effectively reduces the frequency and severity of exacerbations. It is reserved for patients with demonstrated IgE-mediated sensitivity (by positive skin test or radioallergosorbent test [RAST] to common allergens) and an IgE level within a range that can be reduced sufficiently by twice-weekly subcutaneous injections. 

Jacobson KA, von Lubitz DKJE, Daly JW, Fredholm BB (1996) Adenosine receptor ligands differences with acute and chronic treatment. Trends Pharmacol Sci 17(3) 108-113 Jacobson KA, Ji X-D, Li AH, Melman N, Siddiqui MA, Shin KJ, Marquez VE, Ravi RG (2000) Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists. J Med Chem 43(ll) 2196-2203... 

When studied under more controlled conditions using the eug-lycemic hyperinsulinemic clamp method, it is apparent that chronic treatment of insulin-resistant rats with PPARy agonists can substantially improve peripheral insulin-stimulated glucose disposal and the ability of insulin to suppress hepatic glucose production (67, 71, 72). 

Tolerance develops rapidly following acute or chronic treatment with peptidic or nonpeptidic delta agonists [67-71]. For example, Figure 3 shows dose-effect curves for SNC80 administered alone or 24 h after pretreatment with SNC80 (1.0-10 mg/kg) in an assay of schedule-controlled responding for food reinforcement in rhesus monkeys [71]. Under control conditions, SNC80... 

Fig. 4. Spatial delayed performance in rhesus monkeys following chronic treatment with the D2 receptor antagonist haloperidol, and the short-term remediation produced by acute treatment with the Dl receptor agonist ABT 431, as well as the longer term benefit produced by that acute treatment. Adapted from Castner et al. (2000).

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