Agents, empirical screening

At present, the cardinal consideration for the rational design of chemotherapeutic agents is the choice of appropriate biochemical pathways for selective inhibition. Recent developments in the chemotherapy of falciparum malaria exemplify the potential advantages of rational design over empirical screening of compounds. Four years of effort and great expense were required to screen 100,000 compounds for antimalarial activity and the results were essentially negative.The presently preferred... 

Empirical Screening of Flavoring Agents, Enhancers, and Spices... 

The empirical screening approach can, at times, lead to successful development of improved animal food flavoring agents as... 

Both the benefits and toxicides of mechlorethamine stimulated a worldwide search for new antineoplastic agents. In the United States, the National Cancer Institute (NCI) had been established in 1937 and was already empirically studying plant extracts for anticancer activity. In 1955, the NCI established the Cancer Chemotherapy National Service Center to systematically screen drugs in vitro and in vivo. NSC numbers were assigned to each new drug screened and the number now exceeds 720 000. Over the past half century, a growing understanding... 

It may be possible to modify the membrane in such a way as to reduce or eliminate the binding of a fouling agent. These modifications can be tested empirically or screened theoretically if the nature of the foulant is known. 

With an applied current of 2 A, the variation in cathode current density is from approximately 2,5 to 85mAcm which covers the working range of most electroplating baths. The Hull cell is also useful as an empirical development tool, e.g. for rapid screening tests on addition agents. The fundamental cell has been modified, for special purposes, in numerous ways. e.g. a bottomless cell may... 

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