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Adverse drug reactions gastrointestinal

Non-steroidal anti-inflammatory drugs are associated with severe adverse drug reactions e.g. heart failure and gastrointestinal bleeding... [Pg.44]

The cephalosporins have good safety profiles. The overall incidence of adverse events attributed to cephalosporins is between 1 and 10%. The most common adverse drug reactions are rashes (1-5%), eosinophilia (3-10%), gastrointestinal symptoms (3%), hematological abnormalities (1-2%), phlebitis (2%), and fever (<1%). Anaphylactic reactions to cephalosporins are rare (<0.02%). [Pg.533]

A Norwegian study by Olav Spigset utilizing that country s Adverse Drug Reactions Monitor Center reviewed 1,202 reports describing 1,861 adverse reactions to SSRIs. Again, the pattern of reports for the individual SSRIs (citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline) was very similar, with three exceptions. Fluvoxamine reports were comparatively elevated for gastrointestinal symptoms, fluoxetine... [Pg.140]

The overall incidence of adverse reactions to diclofenac is about 30%, but less than 1% of patients have to have treatment withdrawn for this reason. The manufacturers analysis of 1966 adverse effects in 987 patients over about 6 years, when over 30 million patients had been treated, provided some interesting quantitative data. Of the total number of adverse reactions, 34% were gastrointestinal and 16% hematological. Worldwide experience with diclofenac showed that the incidences of serious adverse drug reactions in phase III short-term trials (1227 patients) and long-term trials (1173 patients) in the USA were respectively as follows (1) ... [Pg.1109]

SSZ is another DMARD often used in the treatment of RA. It is estimated that 20-30 % of RA patients on SSZ report adverse drug reactions. Adverse drug events of SSZ are gastrointestinal and hematologic. [Pg.639]

Adverse drug reactions many drugs can cause gastrointestinal disturbance as a side-effect. Those most commonly associated with indigestion include angiotensin-converting enzyme inhibitors... [Pg.95]

It is often possible to address function more specifically in in vitro assays, where functional parameters are usually very sensitive readouts of adverse effects. For example trans-epithelial electrical resistance (TEER) is a very sensitive marker of epithelial disturbances. TEER measures the barrier function of the entire mono-layer and is utilized to study functional disturbances of many epithelial/endothelial cell types including blood-brain barrier, pulmonary, renal, and gastrointestinal cells. Its sensitivity lies in the fact that only a small proportion of cell death has a very large impact on barrier function. Additionally, cell stress can interfere with the arrangement and population of tight junction proteins [16] thus, TEER can in certain conditions measure functional disturbances in the absence of cell death [13]. Also since TEER can be measured noninvasively, it is nondestructive and can be used to monitor the effects of treatment over days and weeks [13, 17]. For excitable cells, electrical activity has also been proven to be an extremely sensitive parameter of adverse drug reactions and microelectrode arrays have been employed successfully to monitor neurotoxicity in vitro [18]. Also, for contractile cells, such as cardiomyocytes, the use of impedance measurements to measure the effects of compounds on spontaneous contraction has been demonstrated to be a very sensitive functional monitoring parameter in vitro [19, 20], Admittedly, none of the aforementioned techniques are true biomarkers per se however, such measurements illustrate the fact that in vitro techniques allow certain possibilities that are not practically tenable in the whole body. [Pg.462]

In a further 10 placebo-controlled trials including 492 patients on Hypericum and 455 patients on placebo, a total of 31 suspected adverse drug reactions were seen in 27 patients treated with Hypericum extract and 49 suspected adverse drug reactions were documented for 34 patients who took placebo [234, 235, 239, 240, 242, 249, 250, 251, 252]. Gastrointestinal symptoms were reported most frequently with 12 cases under Hypericum treatment and 10 cases in placebo groups. Other symptoms such as tiredness (Hypericum 2 cases, placebo 1 case), sleep disturbances (2 cases under either treatment) were very rare. [Pg.704]

Monitoring and Managing Adverse Reactions It is important to observe the patient receiving an NSAID for adverse drug reactions tliroughout tlierapy. Because tliese dru have many adverse reactions, tlie nurse notifies the primary healtli care provider of any complaints tlie patient may hava Gastrointestinal reactions are the most common and can be severe and sometimes fatal, especially in those prone to upper gastrointestinal diseasa... [Pg.164]

ADRs are certainly the most important form of iatrogenic (i.e. doctor-induced) disease. Many of the serious reactions that occur are well-recognised and potentially preventable - e.g. bleeding with warfarin, the upper gastrointestinal effects of NSAIDs. In public health terms, it is not newly introduced drugs that are responsible for most of the population burden of adverse drugs reactions but those whose safety profile is well-established (see below). [Pg.21]


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See also in sourсe #XX -- [ Pg.137 , Pg.140 ]




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