Adsorption therapy with activated

These observations in 1960s-1970s led to the conclusion that AC is not sufficiently haemocompatible i.e., compatible with blood) and the solution to this problem was found in coating activated carbon granules with a more biocompatible material such as cellulose or albumin (Fig. 2a) [9,10,14]. Although AC coating resolved the problem of its poor biocompatibility, it created another one, which restricted use of adsorption therapy in comparison with alternative blood purification tediniques such as dialysis or filtration. The reason for such a restriction is rather obvious a 0.5-5 pm thick semi-pemieable coating (i) slows down the... 

Allergic reactions should be treated appropriately with supportive care, maintenance of airway, breathing, and circulation, and antihistamines plus steroids as needed. Discontinue potassium iodide administration and provide symptomatic and supportive care. The extent of iodide adsorption to activated charcoal has not been determined. Plasma iodide levels do not guide therapy the potassium level should be checked. 

The attachment of proteins and other biomolecules to PEG-grafted surfaces is also of interest for a number of applications. In solid-phase immunoassay and extracorporeal therapy, antibodies or other bioactive molecules are immobilized to a support that interacts with cells, blood, or plasma. Biocompatibility of implants and artificial organs can be improved by the attachment of growth factors to the surface via PEG spacers. These applications are all based on the regulating function of PEG in the interaction between a biomolecule, usually a protein, and another biomolecule or cell. More specifically, immobilization of the biologically active molecules to the free end of grafted PEG chains offers a way to minimize the interactions (deformation and nonspecific adsorption) of attached biomolecules with underlying surface, thus maximize the functions of immobilized biomolecules. 

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