Admixture with diet

The food additive is normally administered by admixture with the diet. Additives intended for use with drinks may be dissolved in the drinking water. If the test substance is not stable in the food or water, or if the animals find the treated diet unappetizing, the additive may be given as a solution or suspension by oral gavage. If gavage administration is used, the dose volumes should be adjusted to body weight at least every 3 days. 

Ref Hackh s Diet (1944), 367-R Note Someone has reported that gambir was used in admixture with K chlorate in some safety explosives ... 

Selection of a compound for toxicity testing often raises many different questions that need to be addressed in advance of biological experimentation. These issues include the decision on specification of the test material, the nature and concentrations of trace impurities, as well as the changes that occur on storage or admixture with animal diets. 

Equipment for Sample Preparation and Analysis 1. Needle manifold for drying samples with a nitrogen stream 2. Probe sonicator with narrow tip and variable, pulsatile energy delivery 3. Lyophilizer for drying diet-drug admixtures and feces... 

Jones (36) reviewed the natural antinutrients of cottonseed protein products— gossypol and the cyclopropenoic fatty acids (CPFA malvalic and sterculic acids). The CPFAs participate in forming the pink color complex in the Halphen reaction, a test specific for the admixture of cottonseed oil with other oils and fats. They also inhibit A9 desamrase, an enzyme that converts stearic acid into oleic acid, and thus increase hardness of fats from animals (e.g., pig backfat and lard) raised or finished on feedstuffs containing high levels of polyunsamrated oils like corn. Feed industry practice is to limit cottonseed lipids to no more than 0.1-0.2% in the diet of laying hens to avoid pink discoloration of egg whites and alterations of the vitelline membrane that cause pasty yolks. 

The food and milk interactions are established, clinically important, and result in an increase in the bioavailability of ciclosporin. The situation should therefore be monitored if any changes are made to the diet of patients taking ciclosporin. Patients should be warned because increased ciclosporin levels are associated with increased nephrotoxicity. Lipid admixtures in parenteral nutrition do not appear to affect ciclosporin pharmacokinetics and it is speculated that they may protect against ciclosporin-induced nephrotoxicity. Close supervision and monitoring is required. There is insufficient evidence to allow extrapolation of the results to bone-marrow transplant recipients with risk factors such as dysli-pidaemia, liver, or renal impairment. ... 

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