Adhesives function

Substances which function as tissue adhesives have the unique ability to remain in contact with tissues in localized areas for prolonged periods of time. Not only does the tissue adhesive function as a glue but it has the capacity to serve as a slow release mechanism for drug delivery as it is biodegraded. 

The classical cadherins are translated as precursor because they are N-terminally cleaved to reveal the mature proteins. This processing is required to activate the cell adhesion function of cadherins. Cadherins interact in trans (i.e., from opposite cells) via the most N-terminal cadherin rqDeats. A short amino acid sequence within this repeat, histidine-alanine-valine (HAV), has been implicated in mediating cell-cell contacts as HAV peptides can disrupt cadherin-dependent cell adhesion. Besides the trans-interactions of cadherins, the extracellular domains are also capable of forming cis-dimers through lateral amino acid contacts between cadherin molecules on one cell. This dimerization again mainly involves the first cadherin repeat. A zipper model based on the pattern of alternating cis- and trans-dimers [1] for the adhesive interactions has been proposed. 

McDermott DH, Fong AM, Yang Q, et al. Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans. J Clin Invest 2003 111(8) 1241— 1250. 

Aota S, Nomizu M, Yamada KM (1994) The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function. J Biol Chem 269 24756-24761... 

Whether the adhesive function is structural or protective, proper pretreatment of the aluminum prior to epoxy bonding remains essential for developing high bond strengths. (1-8)... 

The efficiency of the surface bound siderophores in capturing bacteria was found to depend on the surface-adhesive functional groups, the length of the spacer, the ability to form defined surface layers or monolayers and the topology of the siderophore. 

Finally, for practical reasons it is useful to classify polymeric materials according to where and how they are employed. A common subdivision is that into structural polymers and functional polymers. Structural polymers are characterized by - and are used because of - their good mechanical, thermal, and chemical properties. Hence, they are primarily used as construction materials in addition to or in place of metals, ceramics, or wood in applications like plastics, fibers, films, elastomers, foams, paints, and adhesives. Functional polymers, in contrast, have completely different property profiles, for example, special electrical, optical, or biological properties. They can assume specific chemical or physical functions in devices for microelectronic, biomedical applications, analytics, synthesis, cosmetics, or hygiene. 

Lewandowska K, Balachander N, Sukenik CN et al (1989) Modulation of fibronectin adhesive functions for fibroblasts and neural cells by chemically derivatized substrata. J Cell Physiol 141 (2) 334—345... 

Lu, G., Shimaoka, M., Ferzly, M., Oxvig, G., Takagi, J., and Springer, T. A. (2001b). An isolated, surface-expressed I domain of the integrin aL/12 is sufficient for strong adhesive function when locked in the open conformation with a disulfide. Proc. Natl. Acad. Sci. USA 98, 2387-2392. 

Tandon NN, Ockenhouse CF, Greco NJ, Jamieson GA Adhesive functions c( platelets lacking glycoprotein IV (CD36). Blood 78 2809-2813,1991... 

If quarry or ceramic tile is adhered to the concrete substrate with a strong adhesive, exactly the same rules as for the monolithic should be followed, including stress relief, since the adhesive functions in an identical manner. The tile must be cut to place the expansion jo-int in the tile exactly over the one in the substrate. On the other hand, if the floor is protected by "acid brick" laid on a membrane, the membrane acts as a "sliding joint" as described earlier, and the expansion joint in the brickwork may be offset by as much as a brick length from the point of movement in the substrate—saving the installer the cost of cutting brick to match exactly the expansion joint in the slab. 

Functional biomaterial surfaces that absorb proteins minimally are desirable in prolonging the lifetime of medical implants and providing a clean background for introducing specific cell adhesion functionalities. Nonspecific protein adsorption occurs in various degrees to all surfaces, but more readily to hydro-phobic and positively charged surfaces. To date, the most effective way to minimize nonspecific protein and cell adhesion is to use surfaces comprised of chains of polyethylene oxide (PEO also named polyethylene glycol, or PEG). ... 

An ideal bond coat should have several characteristics that include uncompromised biocompatibility, good adhesion to both the metal substrate and the osseoconductive top coat, and a well-defined melting point to allow application of thermal spray technology. The adhesive function of the bond coat has been loosely compared to the action of a double-sided adhesive tape. 

John.son, G., and Moore, S, W, (1999). The adhesion function on acetylcholinesterase is located at the peripheral anionic site. Btochem. Biophys Res, Commun. 258, 758-762. 

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