Adenovirus-mediated overexpression

George, S.J., C.T. Lloyd, G.D. Angehni,A.C. Newby, and A.H. Baker, Inhibition of late vein graft neointima formation in human and porcine models by adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-3. Circulation, 2000.101(3) 296-304. 

Villarreal, F.J., Lee, A.A., Dillmann, W.H., and Giordano, F.J. 1996. Adenovirus-mediated overexpression of human transforming growth factor-beta 1 in rat cardiac fibroblasts, myocytes and smooth muscle cells. J. Mol. Cell. Cardiol. 28 735-742. 

M. Yagi, E. Magal, Z. Sheng, K. A. Ang, and Y. Raphael, Hair cell protection from aminoglycoside ototoxicity by adenovirus-mediated overexpression of glial cell line-derived neurotrophic factor. Hum. Gene Ther., 10 (1999) 813-823. 

Wang, N., Verna, L., Hardy, S., Forsayeth, J., Zhu, Y., and Stemerman, M.B., Adenovirus-mediated overexpression of c-Jun and c-Fos induces intercellular adhesion molecule-1 and monocyte chemoat-tractant protein-1 in human endothelial ce]is. Arteriosclerosis, Thrombosis Vascular Biol, 19,2078-2084, 1999. 

Seidler, T., Miller, S. L., Loughrey, C. M., Kania, A., Burow, A., Kettlewell, S., Teucher, N., Wagner, S., Kogler, H., Meyers, M. B. Hasenfuss, G, and G.L. Smith, 2003, Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Circ. Res. 93, 132-139. 

Shah AS, Lilly RE, Kypson AP, Tai O, Hata JA, Pippen A, Silvestry SC,Lefkowitz RJ, Glower DD, Koch WJ. Intracoronary adenovirus-mediated delivery and overexpression of the p2-adrenergic receptor in the heart prospects for molecular ventricular assistance. Circulation. 2000 101 408-414. 

Li X, Marani M, Yu J et al. Adenovirus-mediated Bax overexpression for the induction of therapeutic apoptosis in prostate cancer. Cancer Res 2001 61 186-191. 

Xing Z, Braciak T, Jordana M, Croitoru K, Graham FL, Gauldie J. Adenovirus-mediated cytokine gene transfer at tissue sites overexpression of IL-6 induces lymphocytic hyperplasia in the lung. J Immunol 1994 153 4059-4069. 

Giuliano M, Catalano A, Strizzi L, Vianale G, Capogrossi M, Procopio A. Adenovirus-mediated wild-type p53 overexpression reverts tumourigerricity of human mesothelioma cells. Int J Mol Med 2000 5(6) 591-596. 

Partovian C, Adnot S, Ralfestin B, Louzier V, et al. Adenovirus-mediated lung vascular endothelial growth factor overexpression protects against hypoxic pulmonary hypertension in rats. Am J Respir Cell Mol Biol 2000 23 762-771. 

However, Hyal-2 can function as an oncogene. Overexpression accelerates tumor formation.120 It is also a cell surface receptor for some retroviruses, the envelope protein of which mediates oncogenic transformation.121,122 Paradoxically, Hyal-2 under some conditions functions as a TSG product. Hyal-2 can accelerate apoptosis.123 Furthermore, an adenovirus-Hyal-2 vector suppresses growth of tumor xenografts in mice.124 Finally, Hyal-2-over-expressing clones of src-transformed fibroblasts have reduced rates of proliferation (B. Flamion, pers. commun.). Many of these apparent contradictions will become resolved, once the HA catabolic scheme is better understood. 

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