Adenosine triphosphate-binding cassette transporters

ElAli, A., Urrutia, A., Rubio-Araiz, A., et al., 2012. Apolipoprotein-E controls adenosine triphosphate-binding cassette transporters ABCBl and ABCCl on cerebral microvessels after methamphetamine intoxication. Stroke 43,... 

Kooij, G., Mizee, M.R., Van, H.J., et al., 2011. Adenosine triphosphate-binding-cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes relevance to multiple sclerosis pathogenesis. Brain 134,... 

Chapman, L.P., Epton, M.J., Buckingham, J.C., Morris, J.F., and H.C. Christian, 2003, Evidence for a role of the adenosine S -triphosphate-binding cassette transporter A1 in the externalization of annexin I from pituitary folliculo-stellate cells. Endocrinology.l44(3) 1062—73. 

P-Glycoprotein (P-gp), a member of the adenosine triphosphate (ATP)-binding cassette family of membrane transporters, is encoded by the human multidrug-resistance (MDRl, ABCBl) gene (15). This integral membrane protein serves as an... 

ABC ATP CDX CNT ENT EMT GIT GO NCE PEPT1 PMT QSAR SAR SLC ATP-binding cassette Adenosine 5 -triphosphate Caudal-type homeobox transcription factor Concentrative nucleoside transporter Equilibrative nucleoside transporter Epithelial-mesenchymal transition Gastrointestinal tract Gene ontology New chemical entity Di/tri-peptide transporter 1 Pharmacogenetics of Membrane Transporters Project Quantitative structure-activity relationship Structure-activity relationship Solute carriers (SLCs)... 

Carrier-mediated transport of drugs and their metabolites has recently been recognized as an important issue in pharmaceutical research. There is a wealth of information that suggests that transporters are responsible both for the uptake and efflux of drugs and other xenobiotics, and may be key determinants of the disposition of a drug [91,92]. Transporter proteins are divided into two categories (1) the adenosine triphosphate (ATP) binding cassette (ABC) transporter superfamily and (2) the solute carrier (SLC) family of proteins. 

MDR is a major issue for cancer chemotherapy that must be overcome for the successful use of many anti-cancer agents. One member of the adenosine triphosphate (ATP)-binding cassette (ABC) superfamily of membrane transporters that has been studied extensively for molecular imaging purposes has been the 170 kDa transmembrane glycoprotein, P-glycoprotein (Pgp). Two widely studied Tc-labeled agents that have been used for SPECT imaging of MDR... 

The distribution of the lipids between the inner and outer leaflet of a biological membrane is asymmetric, with the outer surface being enriched in phosphatidylcholine (PC) and the inner, cytosolic surface in phos-phatidylethanolamine (PE) and phosphatidylserine (PS). As a result, the outer lipid membrane surface is electrically neutral and the inner negatively charged. Spontaneous randomization (flip-flop) of zwitterionic lipids between the two leaflets is extremely slow. Specific transport proteins, belonging to the adenosine triphosphate (ATP) binding cassette, further maintain lipid asymmetry. Lipid asymmetry may play a role for the proper orientation of membrane proteins. 

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