Human equilibrative nucleoside transporter

Lee, E.-W., Lai, Y, Zhang, H. and Unadkat, J.D. (2006) Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENTl) Implications for interspecies differences in mitochondrial toxicity of fialuridine. The Journal of Biologiccd Chemistry, 281 (24), 16700-16706. 

Iqbal N, Akula MR, Vo D et al (1998) Synthesis, rotamer orientation, and calcium channel modulation activities of alkyl and 2-phenethyl 1, 4-dihydro-2, 6-dlmethyl-3-nltro-4-(3- or 6-substltuted-2-pyrldyl)-5-pyridinecarboxylates. J Med Chem 41 1827-1837 LI RWS, Tse CM, Man RYK et al (2007) Inhibition of human equilibrative nucleoside transporters by dihydropyridine-type calcium channel antagonists. Eur J Pharmacol 568 75-82 Cosconatl S, Marlnelli L, Lavecchia A et al (2007) Characterizing the 1,4-dlhydropyrldlnes... 

Owen, R.P., Lagpacan, L.L., Taylor, T.R., De LaCruz, M., Huang, C.C., Kawamoto, M., Johns, S.J., Stryke, D., Ferrin, T.E. and Giacomini, KM. (2006) Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2. Drug Metabolism and Disposition The Biological Fate of Chemicals, 34 (1), 12-15. 

Vickers, M.E., Mani, R.S., Sundaram, M., Hogue, D.L., Young, J.D., Baldwin. S.A., and Cass, C.E. (1999) Eunctional production and reconstitution of the human equilibrative nucleoside transporter (hENTl) in Saccharomyces cerevisiae. Interaction of inhibitors of nucleoside transport with recombinant hENTl and a glycosylation-defective derivative (hENTl/N48Q). The Biochemical Journal, ii9 (Pt 1). 21—32,... 

Vickers, M.F., Zhang, J., Visser, F., Tackaberry, T, Robins, M.J., Nielsen, L.P., Nowak, L, Baldwin, S.A., Young, J.D., and Cass, C.F. (2004) Uridine recognition motifs of human equilibrative nucleoside transporters 1 and 2 produced in Saccharomyces cerevisiae. Nucleosides, Nucleotides and Nucleic Acids, 23 (1—2), 361-373. 

Molina-Arcas, M., Moreno-Bueno, G., Cano-Soldado, P., Hemandez-Vargas, H., Casado, F.J., Palacios, and Pastor-Anglada, M. (2006) Human equilibrative nucleoside transporter-1 (hENTl) is required for the transcriptomic response of the nudeoside-derived drug 5 -DFUR... 

Spratlin, J., Sangha, R., Glubrecht, D., Dabbagh, L., Young, J.D., Dumontet, C., Cass, C., Lai, R., and Mackey, J.R. (2004) The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. Clinical Cancer Research, 10 (20), 6956-6961. 

Lai, Y, Tse, C. M., Unadkat, J. D. (2004). Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENTl) results in enhanced mitochondrial toxicity of antiviral drugs. The Journal of Biological Chemistry, 279(6), 4490 497. 

Molecular cloning studies in Leishmania and trypanosomes have revealed that all known purine transporters in these parasites are members of the ENT family described above. These proteins have 11 predicted transmembrane domains with the NH2- and COOH termini located on the inside and outside of the plasma membrane respectively (Fig. 4), and this topological model has been tested for the human equilibrative nucleoside transporter hENTl. Four Leishmania ENT permeases have been characterized, NTl (represented by two isoforms, NTl.l and NTl.2), NT2, NT3 and NT4, with the majority of the work on jqjj 6,57-59 Jjeing performed using the genes from L. donovani and the... 

Visser F, Zhang J, Raborn RT et al. Residue 33 of human equilibrative nucleoside transporter 2 is a functionally important component of both the dipyridamole and nucleoside binding sites. Mol Pharmacol 2005 67(4) 1291-1298. 

Ward JL, Sherali A, Mo ZP et al. Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENTl and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. ENT2 exhibits a low affinity for guanosine and cytidine but a high affinity for inosine. J Biol Chem 2000 275(12) 8375-8381. 

Robins MJ, Peng Y, Damaraju VL, Mowles D, Barron G, Tackaberry T, Young JD, Cass CE (2010) Improved syntheses of 5 -5 -(2-aminoethyI)-6-A-(4-nitrobenzyl)-5 -thioadenosine (SAENTA), analogues, and fluorescent probe conjugates analysis of ceU-surface human equilibrative nucleoside transporter 1 (hENTl) levels for prediction of antitumour efficacy of gemcitabine. J Med Chem 53 6040-6053... 

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