Multiple sclerosis pathogenesis

Lassmann H, Bmck W, Lucchinetti C (2001) Heterogeneity of multiple sclerosis pathogenesis Implications for diagnosis and therapy. Trends Mol Med 7 115-121. 

Liuzzi GM, Latronico T, Fasano A, Carlone G, Riccio P (2004) Inter-feron-beta inhibits the expression of metalloproteinases in rat glial cell cultures Implications for multiple sclerosis pathogenesis and treatment. Mult Scler 10 290-297. 

Kooij, G., Mizee, M.R., Van, H.J., et al., 2011. Adenosine triphosphate-binding-cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes relevance to multiple sclerosis pathogenesis. Brain 134,... 

Franklin RJ (2002) Why does remyehnation fail in multiple sclerosis Nat Rev Neurosci 3 705-714 Fratkin JD, Leis AA, Stokic DS, Slavinski SA, Geiss RW (2004) Spinal cord neuropathology in human West Nile virus infection. Arch Pathol Lab Med 128 533-537 Frohman EM, Racke MK, Raine CS (2006) Multiple sclerosis - the plaque and its pathogenesis. N Engl J Med 354 942-955... 

Steinman, L., Martin, R., Bernard, C. etal. Multiple sclerosis deeper understanding of its pathogenesis reveals new targets for therapy. Annu. Rev. Neurosci. 25 491-505,2002. 

Lucchinetti, C., Bruck, W., Parisi, J. etal. Heterogeneity of multiple sclerosis lesions implications for the pathogenesis of demyelination. Ann. Neurol. 47 707-717, 2000. 

Kim, J. K., Mastronardi, F. G., Wood, D. D. etal. Multiple sclerosis an important role for post-translational modifications of myelin basic protein in pathogenesis. Mol. Cell. Proteomics 2 453-462, 2003. 

Paz Soldan, M. M. and Rodriguez, M. Heterogeneity of pathogenesis in multiple sclerosis implications for promotion of remyelination. /. Infect. Dis. 186(Suppl 2) S248-S253, 2002. 

Multiple sclerosis (MS) is a devastating disease of the CNS that produces demyelination and inflammation. It is believed that its pathogenesis involves an immune reaction against various components of the myelin sheath. In a study by Lock et al. (2002), the gene expression patterns of brain lesions obtained during autopsies of MS patients were examined by microarray cluster analysis. A total of 1080 genes (from 7026 represented... 

The Destructive Alliance Interactions of Leukocytes, Cerebral Endothelial Cells, and the Immune Cascade in Pathogenesis of Multiple Sclerosis Alireza Minagar, April Carpenter, and J. Steven Alexander... 

The Role of CD4 T Cells in the Pathogenesis of Multiple Sclerosis Tanuja Chitnis... 

Molecular Negativity May Underlie Multiple Sclerosis Role of the Myelin Basic Protein Family in the Pathogenesis of MS Abdiwahab A. Musse and George Harauz... 

IFN 3 is produced in vivo normally by fibroblasts. In humans, only one IFN 3 is found, which has 166 amino acids and a molar mass larger than 20 kDa. The molecule has a disulfide bond as well as an N-linked carbohydrate chain bound to asparagine 80. Structurally, it is characterized by the presence of five a-helices. Recombinant IFN 3 is marketed under the names of Betaferon , Betaseron , Avonex , and Rebif , being indicated for the treatment of multiple sclerosis, since it blocks the secretion of other cytokines involved in the pathogenesis of this disease. 

How do different stunuli lead to CNS inflaimnation in the pathogenesis of HIV-1 associated dementia, Alzheimer s disease, and multiple sclerosis ... 

Hohlfeld R, Meinl E, Weber F, Zipp F, Sclimidt S, Sotgai S, Goebels N, Voltz R, Spuler A, Iglesius A, Wekerle H (1995) Tire role of autoimmune T lymphocytes in tire pathogenesis of multiple sclerosis. Neurology 45 S33—8. 

Lucchinetti CF, Bruck W, Rodriguez M, Lassmann H (1996) Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis. Brain 6(3) 259—274. 

Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H (2000) Heterogeneity of multiple sclerosis lesions Implications for the pathogenesis of demyelination. Ann Neurol 47(6) 707-717. 

Prat A, Antel J (2005) Pathogenesis of multiple sclerosis. Curr Opin Neurol 18 225-230. 

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