Adenosine diphosphate ribosyl

The risk of developing colonic cancer is raised in UC, particularly in those with long-standing extensive disease (Lennard-Jones et al., 1990). The mechanism of this increased susceptibility is unknown, although it is tempting to speculate that it is related to inflammation and resulting oxidative damage to DNA. As yet there is little evidence to support this contention. Markowitz et al. (1988) have reported a decrease in constituent and oxidant-induced adenosine diphosphate ribosyl... 

Markowitz, M.M., Rozen, P., Pero, R.W., Tobi, M. and Miller, D.G. (1988). Hydrogen peroxide induced adenosine diphosphate ribosyl transferase (ADPRT) response in patients with inflammatory bowel disease. Gut 29, 1680-1686. 

Honjo, J., Nishizuka, Y., Hayaishi, O., and Kato, I. (1968) Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis. J. Biol. Cbem. 243, 3553-3555. 

In another important class of regulatory enzymes, activity is modulated by covalent modification of the enzyme molecule. Modifying groups include phosphoryl, adenylyl, uridylyl, methyl, and adenosine diphosphate ribosyl groups (Fig. 6-30). These groups are generally linked to and removed from the regulatory enzyme by separate enzymes. 

Yoshihara K, Tanigawa Y, Burzio L et al. Evidence for adenosine diphosphate ribosylation of Ca2+, Mg2+-dependent endonuclease. Proc Natl Acad Sci USA 1975 72(l) 289-293. 

Zingarelli B, O Connor M, Wong H et al. Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular eneigy depletion in macrophages stimulated with bacterial lipopolysaccharide. J Immunol 1996 156 350-8. 

Okazaki H, Niedergang C, Mandel P (1980) Adenosine diphosphate ribosylation of histone HI by purified calf thymus poly adenosine diphosphate ribose polymerase. Biochimie 62 147-157... 

Poirier GG, Niedergang C, Champagne M, Mazen A, Mandel P (1982) Adenosine diphosphate ribosylation of chicken-erythrocyte histones HI, H5 and high-mobility group proteins by purified calf thymus polyadenosine diphosphate-ribose polymerase. Eur J Biochem 127 437-442... 

Bizec JC, Mandel P, Klethi J (1985) PolyADP-ribosyl polymerase (adenosine diphosphate-ribosyl-transferase) du cristallin de bovides modulations au cours du vieillissement. C R Acad Sci 300 37-41... 

Bermek E (1976) Interactions of adenosine diphosphate-ribosylated elongation factor 2 with ribosomes. J Biol Chem 251 6544-6549... 

Wong M, Miwa M, Sugimura T, Smulson M (1983) Relationship between histone poly (adenosine diphosphate ribosylation) and histone HI phosphorylation using anti-poly (adenosine diphosphate ribose) antibody. Biochemistry 22 2384-2389... 

Malik N, Smulson M (1984) A relationship between nuclear poly (adenosine diphosphate ribosylation) and acetylation post-translational modifications I. Nucleosome Studies Biochemistry 23 3721-3725... 

The recent establishment of a link between ribonucleotide metabolism, specifically the synthesis of the cellular metabolite, diadenosine tetraphosphate, and its relationships with adenosine diphosphate-ribosylation reactions in the cell, presents a significant new target. 

Iglewski BH, Liu PV, Kabat D (1977) Mechanism of action of Pseudomonas aeruginosa exotoxin A Adenosine diphosphate-ribosylation of mammalian elongation factor 2 in vitro and in vivo. Infect Immun 15 138-144... 

Adenosine Diphosphate Ribosylation of Elongation Factor-2 as a Therapeutic Target Genetic... 

Losonczi, J. A., Tian, F., and Prestegard, J. H. (2000). Nuclear magnetic resonance studies of the N-terminal fragment of adenosine diphosphate ribosylation factor 1 in micelles and bicelles Influence of N-myristoylation. Biochemistry 39,3804-3816. 

Woodcock, C. L. F., 1973, Ultrastructure of inactive chromatin, J. Cell Biol. 59 368a. Yoshihara, K., Tanigawa, Y., Burzio, L., and Koide, S. S., 1975, Evidence for adenosine diphosphate ribosylation of Ca , Mg -dependent endonuclease, Proc. Natl. Acad. Sci. USA 72 289. 

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