Polyadenosine diphosphate ribose polymerase

I.U. Schraufstatter, D.B. Hinshaw, PA. Hyslop, R.G. Spragg, and C.G. Cochrane, Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide, /. Clin. Invest. 77 1312 (1986). 

Junod AF, Jornot L, Petersen H. Differential effects of hyperoxia and hydn en peroxide on DNA damage, polyadenosine diphosphate-ribose polymerase activity, and nicotinamide adenine dinucl( -otide and adenosine triphosphate contents in cultured endothelial cells and fibroblasts. J Cell Physiol 1989 140 177-85. 

Okazaki H, Niedergang C, Mandel P (1976) Purification and properties of calf thymus polyadenosine diphosphate ribose polymerase. FEBS Lett 62 255-258... 

Polyadenosine diphosphate ribose poIy(ADP-ribose) polymerase catalyzes the incorporation of the ADP-ribose moiety of NAD into a homopolymer of repeating ADP-ribose units covalently bound to histones and other nuclear protein acceptors [1,2]. This DNA-dependent enzyme, highly stimulated by nicks and DNA fragmentation [3,4], is thought to be involved in several basic functions of the chromatin, especially in DNA repair [5-7]. 

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