Adenoma, thyroid gland

Eight rats had at least one of the tumors tabulated here. In addition, the following miscellaneous tumors were noted 1 rat had cortical adenoma of adrenal gland, 1 had follicular adenoma of thyroid gland, and 1 had pulmonary adenoma. 

Reported estimated doses in the mice were 3,200 and 6,650 mg/kg/day in males and 3,760 and 7,780 mg/kg/day in females (NTP 1986). Hepatocellular adenoma or carcinoma (combined) occurred at significantly increased incidences in low-dose male mice (22/50, p=0.002) and high-dose male mice (18/50, p=0.019) in comparison to controls (8/50) and showed a positive dose-related trend (p=0.021). Incidences of hepatocellular carcinoma alone were not significantly increased in either the low- or high-dose male mice. Slightly elevated incidences of thyroid gland follicular cell adenoma or carcinoma (combined) were... 

Neoplastic effects in the NTP (1986) bioassay included increased incidences of neoplastic nodules in the liver in the male and female rats and hepatocellular adenoma or carcinoma (combined) in the male mice. Slightly elevated incidences of thyroid gland follicular cell tumors were additionally observed in exposed male mice, although the increases were equivocal. No exposure-related neoplastic changes were found in the chronic study of the 77.4% decaBDE mixture (Kociba et al. 1975 Norris et al. 1975a), but the power of this study to detect carcinogenic effects is limited by the very low dose levels in comparison to those tested in the NTP bioassay. 

Extensive iodine absorption from povidone-iodine can cause transient hypothyroidism or in patients with latent hypothyroidism the risk of destabilization and thyrotoxic crisis (SEDA-20, 226 SEDA-22, 263). Especially at risk are patients with an autonomous adenoma, localized diffuse autonomy of the thyroid gland, nodular goiter, latent hyperthyroidism of autoimmune origin, or endemic iodine deficiency (51). 

Hirokawa, M., and Carney, J. A. 2000. Cell membrane and cytoplasmic staining for MIB-1 in hyalin-izing trabecular adenoma of the thyroid gland. Am. J. Surg. Pathol. 24 575-578. 

Miiller-Hbcker, J. 1999. Immunoreactivity of p53, Ki-67, and Bcl-2 in oncocytic adenomas and carcinomas of the thyroid gland. Hum. Pathol. 30 926-933. 

In adult horses, thyroid gland enlargement is usually caused by adenoma of the thyroid gland. These tumors are benign and do not, in the vast majority of instances, alter thyroid function. These masses should be removed surgically if they obstruct the trachea or esophagus or if hypothyroidism can be documented. 

Adenoma Any benign tumor of glandular origin typically found in the adrenal, pituitary, and thyroid glands (note once an adenoma has progressed to malignancy, it is referred to as an adenocarcinoma). 

S-100 protein has also been studied in neoplastic lesions of the thyroid gland. McLaren and Cossar reported positivity in 100% of papillary carcinomas, 75% of follicular carcinomas, 37.5% of follicular adenomas, and 28.5% of papillary hyperplasias. ... 

Bocker W, Dralle H, Dorn G. Thyroglobulin An immunohistochemical marker in thyroid disease. In DeLellis RA, ed. Diagnostic Immunohistochemistry. New York Masson 1981 37-60. Sambade C, Franssila K, Cameselle-Teijeiro J, et al. Hyalinizing trabecular adenoma A misnomer for a peculiar tumor of the thyroid gland. Endocr Pathol. 1991 2 83-91. 

Littlefield et al. (7) rejwrted that the antibiotic sulfamethazine [4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide] induced hyperplasia and adenomas of the thyroid glands in rats. This report and the results of surveys indicating that sulfamethazine residues were present in a large percentage of market milk samples collected in the USA and Canada 2-4) have generated concern about the disposition of sulfamethazine in dairy anim. The studies reported here were initiated to compare the metabolic fate of C-sulfameth-azine 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzene-[U C]sulfonamide when given orally or intravenously to lactating dairy cows. 

Ziram induced thyroid gland C-cell adenoma and lung alveolar/bronchiolar adenoma in male rats [31]. Ziram is not classifiable as to is carcinogenicity to humans. 

Before ultrasound-guided fine-needle aspiration came into use, scintigraphy was believed to be the most important test for the evaluation of nodules in the thyroid gland. Scintigraphy should, however, still be used when the patient with a nodule has low serum thyroid-stimulating hormone (TSH) value, to confirm the diagnosis of a toxic adenoma. 

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