Acute hepatic hemorrhage

In all cases of suspected inflammatory processes of the liver, a portovenous enhanced scan can be regarded as sufficient to answer diagnostic questions. In cases of acute hepatic hemorrhage, it is of clinical interest to de-... 

Jacqnemln, E., Pariente, D., Fabre, M., Huault, G., Valayer, J., Bernard, O. Pehosis hepatis with initial presentation as acute hepatic failure and intraperitoneal hemorrhage in children. J. Hepatol. 1999 30 1146-1150... 

Aflatoxin poisoning is difficult to diagnose early in humans. The first clinical symptoms are anorexia and weight loss. Aflatoxins are associated with hepatocellular damage and necrosis, cholestasis, hepatomas, acute hepatitis, periportal fibrosis, hemorrhage, jaundice, fatty liver changes, cirrhosis in malnourished children, and Kwashiorkor. There is... 

CDC Case Definition A mosquito-borne viral illness characterized by acute onset and constitutional symptoms followed by a brief remission and a recurrence of fever, hepatitis, albuminuria, and symptoms and, in some instances, renal failure, shock, and generalized hemorrhages. Laboratory criteria for diagnosis is (1) fourfold or greater rise in yellow fever antibody titer in a patient who has no history of recent yellow fever vaccination and cross-reactions to other flaviviruses have been excluded or (2) demonstration of yellow fever virus, antigen, or genome in tissue, blood, or other body fluid. 

Cresols are rapidly absorbed through the skin, producing systemic effects. About 20ml of a 90% cresol solution accidentally poured over an infant s head caused chemical burns, cyanosis, unconsciousness, and death within 4 hours. Histopathologic examination showed hepatic necrosis, cerebral edema, acute tubular necrosis of the kidneys, and hemorrhagic effusions from the peritoneum, pleura, and pericardium. The blood contained 12 mg cresol/lOOdl. 

Experience with long-term therapy with danazol is limited. Peliosis hepatis and benign hepatic adenoma have been observed with long-term use. Peliosis hepatis and hepatic adenoma may be silent until complicated by acute, potentially life-threatening intra-abdominal hemorrhage. Therefore, alert the physician to this possibility. Attempts should be made to determine the lowest dose that will provide... 

Qualitative biomarkers of acute oral exposure that are shared with other toxic compounds include a variety of electrocardiogram alterations. Postmortem biomarkers include fatty hepatic degeneration, pulmonary edema and/or congestion, widespread internal hemorrhaging, widespread intracellular fatty deposits, various myocardial damage, hepatic necrosis, hepatic fibrosis, and increased liver weight (see Section 2.2 for more detail). 

TCDD is the most toxic member of the 75 dioxins. It causes death in rats by hepatic cell necrosis. Death can follow a lethal dose by weeks. Acute and subacute exposure result in wasting, hepatic necrosis, thymic atrophy, hemorrhage, lymphoid depletion, chloracne. A by-product of the manufacture... 

Acute and chronic cholecystitis has been reported after floxuridine hepatic artery infusion (3). Chemotherapy in this patient was associated with persistent epigastric pain with radiation to the back which was not accompanied by any fever or white blood cell elevation. Cholecystectomy showed a shrunken, thickened fibrotic gallbladder that was filled with thick, pasty, hemorrhagic material. There were no gallstones. 

Acute exposure to allyl alcohol causes liver and kidney damage. Allyl alcohol is classified as a periportal hepatotoxicant since it selectively damages the periportal region of the liver. Studies have shown that in adult rats, allyl alcohol produces a moderate to marked periportal necrosis with attendant inflammation, hemorrhage, and also decreases hepatic cytochrome P-450, benzphentamine N-demethyla-tion, and ethoxyresorufin 0-deethylation activities by 30%. In immature rats, it lowered both cytochrome P-450 activity (30%) and ethoxyresorufin O-deethylation (75%). Benzphetamine N-demethyl-ation was not significantly affected in immature rats. Intraperitoneal administration of 1.5 mmol kg of allyl alcohol to starved Swiss albino mice causes the development of hemolysis in 50% of the animals. Other toxic effects include renal necrosis, pulmonary edema, and central nervous system effects at higher dose levels. 

CNS depression or hyperexcitability acute hemorrhagic pancreatitis coagulation defects, thrombosis renal damage hepatic damage... 

Cautions Recent major surgery (Coronary artery bypass graft, OB delivery, organ biopsy), cerebrovascular disease, recent GI or GU bleeding, hypertension, mitral stenosis with atrial fibrillation, acute pericarditis, bacterial endocarditis, hepatic/renal impairment, diabetic retinopathy, ophthalmic hemorrhaging, septic thrombophlebitis, occluded AV cannula at an infected site, advanced age, those receiving oral anticoagulants... 

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